Glutamate: Difference between revisions

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*'''Positive Allosteric Modulators'''

A positive allosteric modulator is a substance which indirectly influences the effects of an agonist at a receptor, by binding to a site distinct from that of the agonist binding site. Usually they induce a structural change within the receptor structure.

Many nootropics and ampakine (a class of compounds known to enhance attention span and alertness) drugs are positive modulators of the AMPA glutamate receptor. These include piracetam, aniracetam and unifiram.

Many nootropics and ampakine (a class of compounds known to enhance attention span and alertness) drugs are positive modulators of the AMPA glutamate receptor. These include [[piracetam]], [[aniracetam]] and unifiram.

*'''Antagonists'''

A glutamate receptor [[antagonist]] is a type of receptor drug that inhibits action at glutamate receptors. [[Alcohol|Ethanol]] acts as an antagonist against the NMDA, AMPA and Kainate glutamate receptors, along with several antiepileptic drugs. Many [[dissociatives|dissociative]] drugs are antagonists against the NMDA glutamate receptor, including [[ketamine]], [[MXE]], [[PCP]] and [[DXM]]. [[Tramadol]] and [[ibogaine]] are dual antagonists against the NMDA glutamate receptor and opioid receptors. One atypical antagonist is [[Theanine]], which is not known to produce dissociative anesthesia at any dose, but has other psychoactive properties.

@@ Line 13: / Line 13: @@
 *'''Positive Allosteric Modulators'''
 A positive allosteric modulator is a substance which indirectly influences the effects of an agonist at a receptor, by binding to a site distinct from that of the agonist binding site. Usually they induce a structural change within the receptor structure.
-Many nootropics and ampakine (a class of compounds known to enhance attention span and alertness) drugs are positive modulators of the AMPA glutamate receptor. These include piracetam, aniracetam and unifiram.
+Many nootropics and ampakine (a class of compounds known to enhance attention span and alertness) drugs are positive modulators of the AMPA glutamate receptor. These include [[piracetam]], [[aniracetam]] and unifiram.
 *'''Antagonists'''
 A glutamate receptor [[antagonist]] is a type of receptor drug that inhibits action at glutamate receptors. [[Alcohol|Ethanol]] acts as an antagonist against the NMDA, AMPA and Kainate glutamate receptors, along with several antiepileptic drugs. Many [[dissociatives|dissociative]] drugs are antagonists against the NMDA glutamate receptor, including [[ketamine]], [[MXE]], [[PCP]] and [[DXM]]. [[Tramadol]] and [[ibogaine]] are dual antagonists against the NMDA glutamate receptor and opioid receptors. One atypical antagonist is [[Theanine]], which is not known to produce dissociative anesthesia at any dose, but has other psychoactive properties.