This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Deschloroketamine: Difference between revisions
>Unity Intro modifications to conform to style guidelines. |
>Unity Removed promotional wording in Effects intro, minor effect modifications, grammatics. |
||
| Line 17: | Line 17: | ||
==Pharmacology== | ==Pharmacology== | ||
{{Further|NMDA receptor antagonist}} | {{Further|NMDA receptor antagonist}} | ||
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other [[arylcyclohexylamine]] [[dissociative]]s such as [[3-MeO-PCP]], [[PCP]] and [[MXE]]. With this in mind, DCK is thought to act as an [[NMDA receptor antagonist]]. NMDA receptors, a type of [[glutamate]] receptor, allow for excitatory electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives inactivate the NMDA receptors by blocking them. This disconnection of neurons leads to the general loss of bodily sensation, motor coordination, memory recall and eventually this substance's equivalent of the “[[Visual_disconnection#Holes.2C_spaces_and_voids| | Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other [[arylcyclohexylamine]] [[dissociative]]s such as [[3-MeO-PCP]], [[PCP]] and [[MXE]]. With this in mind, DCK is thought to act as an [[NMDA receptor antagonist]]. NMDA receptors, a type of [[glutamate]] receptor, allow for excitatory electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives inactivate the NMDA receptors by blocking them. This disconnection of neurons leads to the general loss of bodily sensation, motor coordination, memory recall and eventually this substance's equivalent of the “[[Visual_disconnection#Holes.2C_spaces_and_voids|k-hole]].” | ||
==Subjective effects== | ==Subjective effects== | ||
In terms of its subjective effects, this compound feels closer to that of [[ketamine]] and [[MXE]] than more stimulating, non-immobilizing compounds of the same class such as [[3-MeO-PCP]], [[ | In terms of its subjective effects, this compound feels closer to that of [[ketamine]] and [[MXE]] than more stimulating, non-immobilizing compounds of the same class such as [[3-MeO-PCP]], [[O-PCE]] and [[PCP]]. It has therefore come to be considered a more suitable ketamine substitute than many other popular [[arylcyclohexylamines]] currently available on the research chemicals market, although users are advised to exercise extreme caution due to the health risks it may pose if it does possess its speculated antibacterial properties. | ||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
| Line 29: | Line 29: | ||
*'''[[Effect::Muscle relaxation]]''' | *'''[[Effect::Muscle relaxation]]''' | ||
*'''[[Effect::Nausea]]''' | *'''[[Effect::Nausea]]''' | ||
*'''[[Effect::Perception of decreased weight]]''' | *'''[[Effect::Sedation]]''' | ||
**'''[[Effect::Perception of decreased weight]]''' | |||
*'''[[Effect::Physical autonomy]]''' - This is reported to be especially present at low doses and to be decreasing as the dose increases.{{citation needed}} | *'''[[Effect::Physical autonomy]]''' - This is reported to be especially present at low doses and to be decreasing as the dose increases.{{citation needed}} | ||
*'''[[Effect::Physical euphoria]]''' - This is reported to be present even at low doses.{{citation needed}} | *'''[[Effect::Physical euphoria]]''' - This is reported to be present even at low doses.{{citation needed}} | ||
| Line 40: | Line 41: | ||
===Cognitive effects=== | ===Cognitive effects=== | ||
*'''[[Effect::Anxiety suppression]]''' | *'''[[Effect::Anxiety suppression]]''' | ||
*'''[[Effect::Consciousness disconnection]]''' | *'''[[Effect::Consciousness disconnection]]''' | ||
| Line 52: | Line 52: | ||
*'''[[Effect::Dream potentiation]]''' | *'''[[Effect::Dream potentiation]]''' | ||
*'''[[Effect::Existential self-realization]]''' | *'''[[Effect::Existential self-realization]]''' | ||
*'''[[Effect::Cognitive euphoria | *'''[[Effect::Cognitive euphoria]] | ||
*'''[[Effect::Memory suppression]]''' | *'''[[Effect::Memory suppression]]''' | ||
**'''[[Effect::Ego death]]''' | **'''[[Effect::Ego death]]''' | ||
**'''[[Effect::Amnesia]]''' | |||
*'''[[Effect::Immersion enhancement]]''' | *'''[[Effect::Immersion enhancement]]''' | ||
*'''[[Effect::Increased music appreciation]]''' | *'''[[Effect::Increased music appreciation]]''' | ||
| Line 95: | Line 96: | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{Further|Research chemicals#Toxicity and harm potential}} | {{Further|Research chemicals#Toxicity and harm potential}} | ||
The toxicity and long-term health effects of recreational DCK use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because DCK has very little history of human usage. Anecdotal evidence from people who have tried DCK within the community | The toxicity and long-term health effects of recreational DCK use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because DCK has very little history of human usage. Anecdotal evidence from people who have tried DCK within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | ||
As DCK has been speculated to have antibacterial properties,<ref name="patent"></ref> its prolonged use could potentially pose a serious threat to one's health and immune system. | As DCK has been speculated to have antibacterial properties,<ref name="patent"></ref> its prolonged use could potentially pose a serious threat to one's health and immune system. | ||
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this | It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
As with other NMDA receptor antagonists, the chronic use of DCK can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. | As with other NMDA receptor antagonists, the chronic use of DCK can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. | ||
| Line 130: | Line 131: | ||
*[[Designer drug]] | *[[Designer drug]] | ||
*[[Dissociative]] | *[[Dissociative]] | ||
*[[ | *[[O-PCE]] | ||
*[[Ketamine]] | *[[Ketamine]] | ||
*[[MXE]] | *[[MXE]] | ||