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SAM-e: Difference between revisions
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Sam-e is available over the counter and by prescription in the treatment of depression and osteoarthritis. It is generally distributed in enteric coated tablets, which allows the supplement to pass through the low ph environment of the stomach to the gastrointestinal tract, raising the bioavaliability by 600%. <ref>Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156851/</ref> | Sam-e is available over the counter and by prescription in the treatment of depression and osteoarthritis. It is generally distributed in enteric coated tablets, which allows the supplement to pass through the low ph environment of the stomach to the gastrointestinal tract, raising the bioavaliability by 600%. <ref>Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156851/</ref> | ||
[[File:Sam-E.jpg|250px|thumb|Enteric coated SAM-e tablets.]] | |||
A review of trials assessing oral doses of SAMe between 200mg and 1600mg notes that they appear to have similar efficacy to Tricyclic Antidepressants and more effective than placebo.<ref>A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. | http://www.ncbi.nlm.nih.gov/pubmed/20191258</ref> | A review of trials assessing oral doses of SAMe between 200mg and 1600mg notes that they appear to have similar efficacy to Tricyclic Antidepressants and more effective than placebo.<ref>A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. | http://www.ncbi.nlm.nih.gov/pubmed/20191258</ref> | ||
==Chemistry== | ==Chemistry== | ||
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==Pharmacology== | ==Pharmacology== | ||
Sam-e is an [[endogenous]] molecule that has numerous roles including methyl donation in neurotransmitter synthesis, antioxidative effects (radical scavenging, glutathione precursor), anti-inflammatory effects, and neuroprotective effects<ref>Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702/</ref>. | Sam-e is an [[endogenous]] molecule that has numerous roles including methyl donation in neurotransmitter synthesis, antioxidative effects (radical scavenging, glutathione precursor), anti-inflammatory effects, and neuroprotective effects<ref>Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. | http://www.ncbi.nlm.nih.gov/pubmed/12420702/</ref>. | ||