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2C-D: Difference between revisions
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'''2,5-dimethoxy-4-methylphenethylamine''' (also known as '''2C-M''', and more commonly as '''2C-D''') is a synthetic [[Psychoactive class::psychedelic]] of the [[Chemical class::phenethylamine]] chemical class | '''2,5-dimethoxy-4-methylphenethylamine''' (also known as '''2C-M''', and more commonly as '''2C-D''') is a synthetic [[Psychoactive class::psychedelic]] of the [[Chemical class::phenethylamine]] chemical class that produces short-lived [[psychedelic]] effects comparable to those produced by [[mescaline]] and other [[2C-x]] compounds when [[routes of administration|administered]]. It was first synthesized in 1970 by a team from the Texas Research Institute of Mental Sciences,<ref>Amphetamine analogs. II. Methylated phenethylamines (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/5412084</ref> and its activity in humans was later investigated by [[Alexander Shulgin]].<ref name="isomer">2,5-Dimethoxy-4-chlorophenethylamine (IsomerDesign / PiHKAL) http://isomerdesign.com/PiHKAL/read.php?id=22</ref> | ||
In his book [[PiHKAL]] ("Phenethylamines I Have Known And Loved"), Shulgin lists the dosage range as being from 20 to 60 mg, although now many people regard that as a conservative estimate as it has been learned that substantially higher doses can be taken to induce a full spectrum of classical psychedelic effects while still remaining physically benign, a quality that is unique in the 2C family (e.g. [[2C-P]], [[2C-T-7]]). Lower doses of 2C-D (generally 10 mg or less) have been explored for its use as a potential [[nootropic]], albeit with mixed results.<ref>Lemaire, D. (1990). Erowid 2C-D Vault: Smart Pills, by Hosten & Lazar. Retrieved from https://www.erowid.org/chemicals/2cd/2cd_smartpills1.shtml</ref> | In his book [[PiHKAL]] ("Phenethylamines I Have Known And Loved"), Shulgin lists the dosage range as being from 20 to 60 mg, although now many people regard that as a conservative estimate as it has been learned that substantially higher doses can be taken to induce a full spectrum of classical psychedelic effects while still remaining physically benign, a quality that is unique in the 2C family (e.g. [[2C-P]], [[2C-T-7]]). Lower doses of 2C-D (generally 10 mg or less) have been explored for its use as a potential [[nootropic]], albeit with mixed results.<ref>Lemaire, D. (1990). Erowid 2C-D Vault: Smart Pills, by Hosten & Lazar. Retrieved from https://www.erowid.org/chemicals/2cd/2cd_smartpills1.shtml</ref> | ||
Notably, Shulgin also referred to this substance as a “pharmacological tofu,” meaning it can extend or potentiate the effect of other substances without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with.{{citation needed}} While some people have claimed 2C-D is relatively uninteresting as a psychedelic on its own | Notably, Shulgin also referred to this substance as a “pharmacological tofu,” meaning it can extend or potentiate the effect of other substances without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with.{{citation needed}} While some people have claimed 2C-D is relatively uninteresting as a psychedelic on its own many users have come to strongly disagree with this early assessment and believe that 2C-D is a truly versatile and fully-fledged psychedelic [[entheogen]] in its own right (at the right doses and contexts). | ||
Many who have experimented with this substance report that it is calmer, easier to handle and more comfortable on the body than other closely related [[psychedelic]] [[phenethylamine]]s. While not especially visual or physically euphoric, it is said to be very lucid in its head-space, analytical and cognitively unimpaired, which can readily induce a state of [[euphoria|cognitive euphoria]]. | Many who have experimented with this substance report that it is calmer, easier to handle and more comfortable on the body than other closely related [[psychedelic]] [[phenethylamine]]s. While not especially visual or physically euphoric, it is said to be very lucid in its head-space, analytical and cognitively unimpaired, which can readily induce a state of [[euphoria|cognitive euphoria]]. | ||
Today, 2C-D is used both recreationally and as an [[ | Today, 2C-D is used both recreationally and as an [[entheogenic]] substance, is rarely sold on the streets and almost exclusively obtained online as a gray area [[research chemical]] through the use of private vendors. Albeit being a very functional psychostimulant<ref>Zuba, D., & Sekula, K. (2013). Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Testing and Analysis, 5(8), 634–645. https://doi.org/10.1002/dta.1397</ref><ref>King, L. A. (2014). New phenethylamines in Europe. Drug Testing and Analysis, 6(7–8), 808–818. https://doi.org/10.1002/dta.1570</ref> with very successful studies investigating the use in psychotherapy in Germany,<ref>Schneider, U. (2004). Aspekte des Psychischen: Festschrift anlässlich des 60. Geburtstags von Hinderk M. Emrich. Würzbug, Germany: Königshausen & Neumann. '''No complete fulltext was available at the time of writing, please refer to the Google Scholar document: https://books.google.de/books?id=yo45tYQj2-MC&lpg=PA129&ots=tW1EqmhrGF&dq=DMM-PEA&hl=de&pg=PA129&output=embed.'''</ref> 2C-D has not found widespread use. This has been argued to be due to the previously limited diversity of substances on the market -- a consumer dynamic which has changed significantly with the advent of the internet -- allowing a broader freedom of choice for explorers of psychedelic phenethylamines.<ref>Martin, J. (2014). Drugs on the Dark Net. London: Palgrave Macmillan UK. https://doi.org/10.1057/9781137399052</ref> Of these, it tends to be substantially harder to find and notably more expensive by weight.{{citation needed}} | ||
==Chemistry== | ==Chemistry== | ||