3-FEA: Difference between revisions

Line 74:

The toxicity and long-term health effects of recreational 3-FEA use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is likely because 3-FEA has an extremely short history of human usage, becoming available only in mid-2016. Early anecdotal reports from people within the community who have tried 3-FEA suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

Likely due to its ~~putative~~ serotonin-releasing ~~and [[~~entactogen~~]]ic properties~~, it is possible 3-FEA may display unusually high affinity for the 5-~~HT2b~~ receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use, ~~as seen in other 5-HT2b agonists such as [https://en~~.~~wikipedia~~.~~org/wiki/Fenfluramine fenfluramine] and [[MDMA]]~~.

Likely due to its properties as a [[serotonin]]-releasing entactogen, it is possible 3-FEA may display unusually high affinity for the 5-HT<sub>2B</sub> receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use,<ref>Huang, X. P., Setola, V., Yadav, P. N., Allen, J. A., Rogan, S. C., Hanson, B. J., ... & Roth, B. L. (2009). Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine2B receptor agonists: implications for drug safety assessment. ''Molecular Pharmacology'', 76(4), 710-722. https://doi.org/10.1161/01.CIR.102.23.2836</ref> as seen in other 5-HT<sub>2B</sub> agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]].

~~It is perhaps worth noting that in the field of medicinal chemistry~~, ~~the fluorine substitution is sometimes seen as desirable in central nervous system pharmaceutical agents~~, ~~and is a common practice due to the corresponding increase in lipophilicity granted by the substitute~~.~~<ref>Smart~~, B. E. (~~2001~~). ~~Fluorine substituent effects (on bioactivity)~~. ~~Journal of Fluorine Chemistry~~, ~~109~~(1), 3-11. ~~http~~://~~dx.~~doi.org/10.~~1016~~/~~S0022-1139(~~01~~)00375-X~~.</ref>

It is strongly recommended that one use proper [[responsible drug use|harm reduction practices]] when using this substance.

Line 83:

Line 81:

Although it still remains to be seen, the chronic use of 3-FEA will likely become considered to be [[Addiction potential::moderately addictive with a high potential for abuse]] and capable of causing psychological dependence among a certain population of users. When dependence or addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 3-FEA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. ~~After~~ it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::~~1 -~~ 10 days]] to be back at baseline (in the absence of further consumption). 3-FEA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic and [[serotonin|serotonergic]] [[stimulant]]s]] and [[entactogens]], meaning that after the consumption of 3-FEA all [[stimulant]]s will have a reduced effect (including atypical stimulants one might not expect, like [[MDMA]] or [[amphetamine]] due to its reliance on dopamine and norepinephrine to exert its ~~full euphoric~~ effect).

Tolerance to many of the effects of 3-FEA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. Afterward, it takes about [[Time to half tolerance::3 - 5 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::10 days]] to be back at baseline (in the absence of further consumption). 3-FEA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic and [[serotonin|serotonergic]] [[stimulant]]s]] and [[entactogens]], meaning that after the consumption of 3-FEA all [[stimulant]]s will have a reduced effect (including atypical stimulants one might not expect, like [[MDMA]] or [[amphetamine]] due to its reliance on dopamine and norepinephrine stores to exert the full spectrum of its effect).

===Psychosis===

@@ Line 74: / Line 74: @@
 The toxicity and long-term health effects of recreational 3-FEA use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is likely because 3-FEA has an extremely short history of human usage, becoming available only in mid-2016. Early anecdotal reports from people within the community who have tried 3-FEA suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
-Likely due to its putative serotonin-releasing and [[entactogen]]ic properties, it is possible 3-FEA may display unusually high affinity for the 5-HT2b receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use, as seen in other 5-HT2b agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]].
+Likely due to its properties as a [[serotonin]]-releasing entactogen, it is possible 3-FEA may display unusually high affinity for the 5-HT<sub>2B</sub>  receptor, which like [[MDMA]] and fenfluramine would make it would be cardiotoxic with long-term use,<ref>Huang, X. P., Setola, V., Yadav, P. N., Allen, J. A., Rogan, S. C., Hanson, B. J., ... & Roth, B. L. (2009). Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine2B receptor agonists: implications for drug safety assessment. ''Molecular Pharmacology'', 76(4), 710-722. https://doi.org/10.1161/01.CIR.102.23.2836</ref> as seen in other 5-HT<sub>2B</sub> agonists such as [https://en.wikipedia.org/wiki/Fenfluramine fenfluramine] and [[MDMA]].
-It is perhaps worth noting that in the field of medicinal chemistry, the fluorine substitution is sometimes seen as desirable in central nervous system pharmaceutical agents, and is a common practice due to the corresponding increase in lipophilicity granted by the substitute.<ref>Smart, B. E. (2001). Fluorine substituent effects (on bioactivity). Journal of Fluorine Chemistry, 109(1), 3-11. http://dx.doi.org/10.1016/S0022-1139(01)00375-X.</ref>
 It is strongly recommended that one use proper [[responsible drug use|harm reduction practices]] when using this substance.
@@ Line 83: / Line 81: @@
 Although it still remains to be seen, the chronic use of 3-FEA will likely become considered to be [[Addiction potential::moderately addictive with a high potential for abuse]] and capable of causing psychological dependence among a certain population of users. When dependence or addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
-Tolerance to many of the effects of 3-FEA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After  it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 10 days]] to be back at baseline (in the absence of further consumption). 3-FEA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic and [[serotonin|serotonergic]] [[stimulant]]s]] and [[entactogens]], meaning that after the consumption of 3-FEA all [[stimulant]]s will have a reduced effect (including atypical stimulants one might not expect, like [[MDMA]] or [[amphetamine]] due to its reliance on dopamine and norepinephrine to exert its full euphoric effect).
+Tolerance to many of the effects of 3-FEA [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. Afterward, it takes about [[Time to half tolerance::3 - 5 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::10 days]] to be back at baseline (in the absence of further consumption). 3-FEA presents cross-tolerance with [[Cross-tolerance::all [[dopamine]]rgic and [[serotonin|serotonergic]] [[stimulant]]s]] and [[entactogens]], meaning that after the consumption of 3-FEA all [[stimulant]]s will have a reduced effect (including atypical stimulants one might not expect, like [[MDMA]] or [[amphetamine]] due to its reliance on dopamine and norepinephrine stores to exert the full spectrum of its effect).
 ===Psychosis===