MDMA/Synthesis: Difference between revisions

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= Synthesis =

== Shulgin ==

=== Synthesis ===

* From piperonal (with nitromethane) to the nitroethene; (with electrolytic reduction) to MDPEA (Tanaka and Midzuno, 1929).

* From 3,4-methylenedioxybenzaldehyde (with malonic acid) to 3,4-methylenedioxycin namic acid; (with Na, Hg) to 3,4-methylenedioxypropionic acid; (with NH3) to 3,4-methyl enedioxypropionamide; (with NaOCl) to MDPEA (Slotta and Heller, 1930).

* From 3,4-methylenedioxyhydrocinnamamide (Kindler, 1931).

* From piperonal (with nitromethane) to the nitroethene; (with Pd, H2) to MDPEA (Schales, 1935a; Maurer and Schiedt, 1935).

* Synthesis by catalytic hydrogenation of homopiperonyloximine (Schales 1935b).

* From piperonal (with nitromethane) to the nitroethene; (with LAH) to MDPEA (Erne and Ramirez, 1950; Dallacker et al., 1971).

* From piperonal (with nitromethane) to the nitroethene; (with Raney Ni, or Raney Co, H2) to MDPEA (Reeve and Eareckson, 1950).

* From piperonal (with malonic acid) to 3,4-methylenedioxycinnamic acid; (with Pd, H2) to 3,4-methylenedioxyphenylpropionic acid; (with SOCL2, NH3) to 3,4-methylenedioxyphen ylpropionamide; (with aq. KOCI ) to MDPEA (Habermehl and Khalique, 1967).

* Synthesis by reduction of the 2-nitrophenylethane with Fe powder in ethanol in the presence of ammonium chloride (Ran et al., 2000).

== M. Swist, J. Wilamowski, A. Parczewski ==

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Two hundred milligrams of MDMA HCl was dissolved in 2 ml of buffer. Two different buffers, phosphate buffer, pH 7, and carbonate buffer, pH 10, were tested. The suspension was vigorously shaken (25 min) following by the addition of 200 ml of ''n''-heptane, containing diphenylamine as an internal standard, and then again shaken (25 min). The extracts were subjected to GC/MS analysis and impurity profiles were obtained.

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 = Synthesis =
+== Shulgin ==
+=== Synthesis ===
+* From piperonal (with nitromethane) to the nitroethene; (with electrolytic reduction) to MDPEA (Tanaka and Midzuno, 1929).
+* From 3,4-methylenedioxybenzaldehyde (with malonic acid) to 3,4-methylenedioxycin namic acid; (with Na, Hg) to 3,4-methylenedioxypropionic acid; (with NH3) to 3,4-methyl enedioxypropionamide; (with NaOCl) to MDPEA (Slotta and Heller, 1930).
+* From 3,4-methylenedioxyhydrocinnamamide (Kindler, 1931).
+* From piperonal (with nitromethane) to the nitroethene; (with Pd, H2) to MDPEA (Schales, 1935a; Maurer and Schiedt, 1935).
+* Synthesis by catalytic hydrogenation of homopiperonyloximine (Schales 1935b).
+* From piperonal (with nitromethane) to the nitroethene; (with LAH) to MDPEA (Erne and Ramirez, 1950; Dallacker et al., 1971).
+* From piperonal (with nitromethane) to the nitroethene; (with Raney Ni, or Raney Co, H2) to MDPEA (Reeve and Eareckson, 1950).
+* From piperonal (with malonic acid) to 3,4-methylenedioxycinnamic acid; (with Pd, H2) to 3,4-methylenedioxyphenylpropionic acid; (with SOCL2, NH3) to 3,4-methylenedioxyphen ylpropionamide; (with aq. KOCI ) to MDPEA (Habermehl and Khalique, 1967).
+* Synthesis by reduction of the 2-nitrophenylethane with Fe powder in ethanol in the presence of ammonium chloride (Ran et al., 2000).
 == M. Swist, J. Wilamowski, A. Parczewski ==
@@ Line 81: / Line 95: @@
 Two hundred milligrams of MDMA HCl was dissolved in 2 ml of buffer. Two different buffers, phosphate buffer, pH 7, and carbonate buffer, pH 10, were tested. The suspension was vigorously shaken (25 min) following by the addition of 200 ml of ''n''-heptane, containing diphenylamine as an internal standard, and then again shaken (25 min). The extracts were subjected to GC/MS analysis and impurity profiles were obtained.
+<references/>