Serotonergic psychedelic: Difference between revisions

Line 1:

[[File:molecules.png|~~351px~~|thumb|right|''Psychedelic structural comparison diagram'']]

[[File:molecules.png|315px|thumb|right|''Psychedelic structural comparison diagram'']]

'''Serotonergic psychedelics''' (also known as '''serotonergic [[hallucinogen]]s''') are a class of [[hallucinogenic]] substances with a method of action strongly tied to modifying the normal [[neurotransmitter|neurotransmission]] of [[serotonin]]. Serotonin, which is also ~~commonly~~ referred to as '''5-HT''' (from '''5'''-'''h'''ydroxy-'''t'''ryptamine) is a naturally-occurring neurotransmitter which is tied to developmental, cardiovascular, gastrointestinal, and endocrine function, sensory perception, behaviors such as aggression, appetite, sex, sleep, mood, cognition, and memory, many of which have yet to be fully understood.<ref>David E. Nichols and Charles D. Nichols, Serotonin Receptors. Chemical Reviews. 2008. 108 (5), 1614-1641. https://doi.org/10.1021/cr078224o</ref>

'''Serotonergic psychedelics''' (also known as '''serotonergic [[hallucinogen]]s''') are a class of [[hallucinogenic]] substances with a method of action strongly tied to modifying the normal [[neurotransmitter|neurotransmission]] of [[serotonin]] in the central nervous system (CNS). Serotonin, which is also referred to as '''5-HT''' (from its chemical name '''5'''-'''h'''ydroxy-'''t'''ryptamine) is a naturally-occurring [[monoamine neurotransmitter]] which is tied to developmental, cardiovascular, gastrointestinal, and endocrine function, sensory perception, behaviors such as aggression, appetite, sex, sleep, mood, cognition, and memory, many of which have yet to be fully understood.<ref>David E. Nichols and Charles D. Nichols, Serotonin Receptors. Chemical Reviews. 2008. 108 (5), 1614-1641. https://doi.org/10.1021/cr078224o</ref>

==Method of action==

Line 199:

* Béïque, J. C., Imad, M., Mladenovic, L., Gingrich, J. A., & Andrade, R. (2007). '''''Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex.''''' Proceedings of the National Academy of Sciences, 104(23), 9870-9875.

* Winter, J. C., Fiorella, D. J., Timineri, D. M., Filipink, R. A., Helsley, S. E., & Rabin, R. A. (1999). '''''Serotonergic receptor subtypes and hallucinogen-induced stimulus control'''''. Pharmacology Biochemistry and Behavior, 64(2), 283-293. http://doi.org/10.1016/S0091-3057(99)00063-5.

* David E. Nichols and Charles D. Nichols, Serotonin Receptors. Chemical Reviews. 2008. 108 (5), 1614-1641. https://doi.org/10.1021/cr078224o

* Nichols, D. E. (2004). '''''Hallucinogens.''''' Pharmacology & therapeutics, 101(2), 131-181.

* Vollenweider, F. X., & Kometer, M. (2010). '''''The neurobiology of psychedelic drugs: implications for the treatment of mood disorders.''''' Nature Publishing Group, 11(9), 642–651. https://doi.org/10.1038/nrn2884

@@ Line 1: / Line 1: @@
 {{approval}}
-[[File:molecules.png|351px|thumb|right|''Psychedelic structural comparison diagram'']]
+[[File:molecules.png|315px|thumb|right|''Psychedelic structural comparison diagram'']]
-'''Serotonergic psychedelics''' (also known as '''serotonergic [[hallucinogen]]s''') are a class of [[hallucinogenic]] substances with a method of action strongly tied to modifying the normal [[neurotransmitter|neurotransmission]] of [[serotonin]]. Serotonin, which is also commonly referred to as '''5-HT''' (from '''5'''-'''h'''ydroxy-'''t'''ryptamine) is a naturally-occurring neurotransmitter which is tied to developmental, cardiovascular, gastrointestinal, and endocrine function, sensory perception, behaviors such as aggression, appetite, sex, sleep, mood, cognition, and memory, many of which have yet to be fully understood.<ref>David E. Nichols and Charles D. Nichols, Serotonin Receptors. Chemical Reviews. 2008. 108 (5), 1614-1641. https://doi.org/10.1021/cr078224o</ref>
+'''Serotonergic psychedelics''' (also known as '''serotonergic [[hallucinogen]]s''') are a class of [[hallucinogenic]] substances with a method of action strongly tied to modifying the normal [[neurotransmitter|neurotransmission]] of [[serotonin]] in the central nervous system (CNS). Serotonin, which is also referred to as '''5-HT''' (from its chemical name '''5'''-'''h'''ydroxy-'''t'''ryptamine) is a naturally-occurring [[monoamine neurotransmitter]] which is tied to developmental, cardiovascular, gastrointestinal, and endocrine function, sensory perception, behaviors such as aggression, appetite, sex, sleep, mood, cognition, and memory, many of which have yet to be fully understood.<ref>David E. Nichols and Charles D. Nichols, Serotonin Receptors. Chemical Reviews. 2008. 108 (5), 1614-1641. https://doi.org/10.1021/cr078224o</ref>
 ==Method of action==
@@ Line 199: / Line 199: @@
 * Béïque, J. C., Imad, M., Mladenovic, L., Gingrich, J. A., & Andrade, R. (2007). '''''Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex.''''' Proceedings of the National Academy of Sciences, 104(23), 9870-9875.
 * Winter, J. C., Fiorella, D. J., Timineri, D. M., Filipink, R. A., Helsley, S. E., & Rabin, R. A. (1999). '''''Serotonergic receptor subtypes and hallucinogen-induced stimulus control'''''. Pharmacology Biochemistry and Behavior, 64(2), 283-293. http://doi.org/10.1016/S0091-3057(99)00063-5.
+* David E. Nichols and Charles D. Nichols, Serotonin Receptors. Chemical Reviews. 2008. 108 (5), 1614-1641. https://doi.org/10.1021/cr078224o
 * Nichols, D. E. (2004). '''''Hallucinogens.''''' Pharmacology & therapeutics, 101(2), 131-181.
 * Vollenweider, F. X., & Kometer, M. (2010). '''''The neurobiology of psychedelic drugs: implications for the treatment of mood disorders.''''' Nature Publishing Group, 11(9), 642–651. https://doi.org/10.1038/nrn2884