APICA: Difference between revisions

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'''2NE1''' (also known as '''APICA~~''' or '''JWH-018 adamantyl carboxamide~~''') is a novel synthetic designer [[psychoactive class::cannabinoid]]. It has been shown to act as a potent [[agonist]] for the CB1 and CB2 [[cannabinoid]] [[receptor]]s<ref>Samuel D. Banister, Jordyn Stuart, Richard C. Kevin, Amelia Edington, Mitchell Longworth, Shane M. Wilkinson, Corinne Beinat, Alexandra S. Buchanan, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor, and Michael Kassiou. "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135" Chemical Neuroscience. 2015;6(8);1445-1458;doi:10.1021/acschemneuro.5b00107 (Pubmed / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/25921407</ref> and has been reported to produce subjective effects somewhat similar to that of [[cannabis]], albeit with a short duration and an emphasis on intense physical sensations.

'''2NE1''' (also known as '''APICA''') is a novel synthetic designer [[psychoactive class::cannabinoid]]. It has been shown to act as a potent [[agonist]] for the CB1 and CB2 [[cannabinoid]] [[receptor]]s<ref>Samuel D. Banister, Jordyn Stuart, Richard C. Kevin, Amelia Edington, Mitchell Longworth, Shane M. Wilkinson, Corinne Beinat, Alexandra S. Buchanan, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor, and Michael Kassiou. "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135" Chemical Neuroscience. 2015;6(8);1445-1458;doi:10.1021/acschemneuro.5b00107 (Pubmed / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/25921407</ref> and has been reported to produce subjective effects somewhat similar to that of [[cannabis]], albeit with a short duration and an emphasis on intense physical sensations.

The name 2NE1 appears to be a reference to the South Korean all-girl K-Pop group.<ref>2NE1 (Wikipedia) | https://en.wikipedia.org/wiki/2NE1</ref> It was first identified in Japan as a constituent of a brown powder sold in late 2011 under the name "Fragrance Powder" as a mixture with its [[indazole]] analog [[AKB48]]<ref>Nahoko Uchiyama, Maiko Kawamura, Ruri Kikura-Hanajiri, Yukihiro Goda. "Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide(APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products" Forensic Toxicol (2012) 30: 114-125;doi:10.1007/s11419-012-0136-7 (SpringerLink) | http://link.springer.com/article/10.1007/s11419-012-0136-7</ref> and has since been available for sale as a grey area [[research chemical]] through online vendors.

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 {{SubstanceBox/2NE1}}
-'''2NE1''' (also known as '''APICA''' or '''JWH-018 adamantyl carboxamide''') is a novel synthetic designer [[psychoactive class::cannabinoid]]. It has been shown to act as a potent [[agonist]] for the CB1 and CB2 [[cannabinoid]] [[receptor]]s<ref>Samuel D. Banister, Jordyn Stuart, Richard C. Kevin, Amelia Edington, Mitchell Longworth, Shane M. Wilkinson, Corinne Beinat, Alexandra S. Buchanan, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor, and Michael Kassiou. "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135" Chemical Neuroscience. 2015;6(8);1445-1458;doi:10.1021/acschemneuro.5b00107 (Pubmed / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/25921407</ref> and has been reported to produce subjective effects somewhat similar to that of [[cannabis]], albeit with a short duration and an emphasis on intense physical sensations.
+'''2NE1''' (also known as '''APICA''') is a novel synthetic designer [[psychoactive class::cannabinoid]]. It has been shown to act as a potent [[agonist]] for the CB1 and CB2 [[cannabinoid]] [[receptor]]s<ref>Samuel D. Banister, Jordyn Stuart, Richard C. Kevin, Amelia Edington, Mitchell Longworth, Shane M. Wilkinson, Corinne Beinat, Alexandra S. Buchanan, David E. Hibbs, Michelle Glass, Mark Connor, Iain S. McGregor, and Michael Kassiou. "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135" Chemical Neuroscience. 2015;6(8);1445-1458;doi:10.1021/acschemneuro.5b00107 (Pubmed / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/25921407</ref> and has been reported to produce subjective effects somewhat similar to that of [[cannabis]], albeit with a short duration and an emphasis on intense physical sensations.
 The name 2NE1 appears to be a reference to the South Korean all-girl K-Pop group.<ref>2NE1 (Wikipedia) | https://en.wikipedia.org/wiki/2NE1</ref> It was first identified in Japan as a constituent of a brown powder sold in late 2011 under the name "Fragrance Powder" as a mixture with its [[indazole]] analog [[AKB48]]<ref>Nahoko Uchiyama, Maiko Kawamura, Ruri Kikura-Hanajiri, Yukihiro Goda. "Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide(APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products" Forensic Toxicol (2012) 30: 114-125;doi:10.1007/s11419-012-0136-7 (SpringerLink) | http://link.springer.com/article/10.1007/s11419-012-0136-7</ref> and has since been available for sale as a grey area [[research chemical]] through online vendors.