Serotonin: Difference between revisions

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[[File:Serotonin.png|300px|thumb|right|Skeletal formula of serotonin molecule.]]

'''Serotonin''', also known as '''5-hydroxytryptamine''' ('''5-HT'''), is a monoamine [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.

'''Serotonin''', also known as '''5-hydroxytryptamine''' ('''5-HT'''), is a [[monoamine]] [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.

Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic [[~~neuron|~~neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, and sleep. Serotonin also has some cognitive functions, including memory and learning. In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.

Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic [[neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, and sleep. Serotonin also has some cognitive functions, including memory and learning. In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.

==Chemistry==

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Serotonin is comprised of a monoamine chain attached to an indole ring at the third carbon. A monoamine chain is made up of an amine group attached to an ethane chain. This monoamine chain can be found in many neurotransmitters, including [[histamine|histamine]], [[dopamine|dopamine]], [[adrenaline|adrenaline]] and [[noradrenaline|noradrenaline]]. It's also found in many drugs, examples being [[tryptamines]] and [[phenethylamines]].

==The ~~5-HT system~~==

==The Serotonin System==

The 5-HT ~~receptors, or serotonin~~ receptors, are found in the central nervous system and the peripheral nervous system~~. They exhibit both excitatory and inhibitory [[neuron#neurotransmission|neurotransmission]]~~.

The serotonin receptor, or 5-HT receptors, are found throughout the central nervous system and the peripheral nervous system.

===Drugs targeting the 5-HT system===

@@ Line 1: / Line 1: @@
 [[File:Serotonin.png|300px|thumb|right|Skeletal formula of serotonin molecule.]]
-'''Serotonin''', also known as '''5-hydroxytryptamine''' ('''5-HT'''), is a monoamine [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.
+'''Serotonin''', also known as '''5-hydroxytryptamine''' ('''5-HT'''), is a [[monoamine]] [[neurotransmitter|neurotransmitter]] affecting the [[serotonin]] [[receptors]] (5-HT<sub>1-7</sub>). Serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans. It is popularly thought to be a contributor to feelings of well-being and happiness.
-Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic [[neuron|neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, and sleep. Serotonin also has some cognitive functions, including memory and learning. In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.
+Approximately 90% of the human body's total serotonin is located in the digestive system, where it is used to regulate intestinal movements. The remainder is synthesized in serotonergic [[neurons]] of the CNS, where it has various functions. These include the regulation of mood, appetite, and sleep. Serotonin also has some cognitive functions, including memory and learning. In the blood, it serves as a [[vasoconstriction|vasoconstrictor]], and could be attributed as the cause of vasoconstriction in most serotonergic drugs.
 ==Chemistry==
@@ Line 9: / Line 9: @@
 Serotonin is comprised of a monoamine chain attached to an indole ring at the third carbon. A monoamine chain is made up of an amine group attached to an ethane chain. This monoamine chain can be found in many neurotransmitters, including [[histamine|histamine]], [[dopamine|dopamine]], [[adrenaline|adrenaline]] and [[noradrenaline|noradrenaline]]. It's also found in many drugs, examples being [[tryptamines]] and [[phenethylamines]].
-==The 5-HT system==
+==The Serotonin System==
-The 5-HT receptors, or serotonin receptors, are found in the central nervous system and the peripheral nervous system. They exhibit both excitatory and inhibitory [[neuron#neurotransmission|neurotransmission]].
+{{stub}}
+The serotonin receptor, or 5-HT receptors, are found throughout the central nervous system and the peripheral nervous system.
 ===Drugs targeting the 5-HT system===