Harmala alkaloid: Difference between revisions

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However, it is important to understand that this does not imply that Harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs, which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including; sedation, stimulation, anxiety, dysphoria, euphoria, headaches, eye strain, convulsions, etc.

Since DMT is broken down by monoamine oxidase-A, inhibition of this enzyme allows for the oral activation of DMT, and prolongs the experience for the duration of the harmala alkaloids' effects. In combination, harmala alkaloids and DMT is known as [[Ayahuasca]]~~. this of course is a dirty hack, and a much safer route would be to introduce protective moieties to the DMT molecule itself~~.

Since DMT is broken down by monoamine oxidase-A, inhibition of this enzyme allows for the oral activation of DMT, and prolongs the experience for the duration of the harmala alkaloids' effects. In combination, harmala alkaloids and DMT is known as [[Ayahuasca]].

==Examples==

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Tetrahydroharmine does not inhibit monoamine oxidase A. Instead, it weakly inhibits [[serotonin]] reuptake. At dosages of 200mg, it has been reported to cause dream-like euphoria, pleasurable tingling sensations and a head space similar to that of [[LSD]].

Note: all three of these dosages seem wildly exaggerated to me. 100 molecules of harmaline will inhibit 100 molecules of MAO-A, since it must bind with the enzyme. Effective inhibition dose could be calculated by determining the concentration of MOA in the body. Harmine is certainly active at <100mg, and the synergistic property of combined harmala alkaloids as found within Peganum Harmala likely increases their efficacy; two MAO-A inhibitors will be more effective with less side effects than a higher quantity of one alkaloid alone.

Note: all three of these dosages seem wildly exaggerated to me. 100 molecules of harmaline will inhibit 100 molecules of MAO-A, since it must bind with the enzyme. Effective inhibition dose could be calculated by determining the concentration of MOA in the body. Harmine is certainly active at <100mg, and the synergistic property of combined harmala alkaloids as found within Peganum Harmala likely increases their efficacy; two MAO inhibitors will be more effective with less side effects than a higher quantity of one alkaloid alone.

==Toxicity and Harm Potential==

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 However, it is important to understand that this does not imply that Harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs, which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including; sedation, stimulation, anxiety, dysphoria, euphoria, headaches, eye strain, convulsions, etc.
-Since DMT is broken down by monoamine oxidase-A, inhibition of this enzyme allows for the oral activation of DMT, and prolongs the experience for the duration of the harmala alkaloids' effects. In combination, harmala alkaloids and DMT is known as [[Ayahuasca]]. this of course is a dirty hack, and a much safer route would be to introduce protective moieties to the DMT molecule itself.
+Since DMT is broken down by monoamine oxidase-A, inhibition of this enzyme allows for the oral activation of DMT, and prolongs the experience for the duration of the harmala alkaloids' effects. In combination, harmala alkaloids and DMT is known as [[Ayahuasca]].
 ==Examples==
@@ Line 31: / Line 31: @@
 Tetrahydroharmine does not inhibit monoamine oxidase A. Instead, it weakly inhibits [[serotonin]] reuptake. At dosages of 200mg, it has been reported to cause dream-like euphoria, pleasurable tingling sensations and a head space similar to that of [[LSD]].
-Note: all three of these dosages seem wildly exaggerated to me. 100 molecules of harmaline will inhibit 100 molecules of MAO-A, since it must bind with the enzyme. Effective inhibition dose could be calculated by determining the concentration of MOA in the body. Harmine is certainly active at <100mg, and the synergistic property of combined harmala alkaloids as found within Peganum Harmala likely increases their efficacy; two MAO-A inhibitors will be more effective with less side effects than a higher quantity of one alkaloid alone.
+Note: all three of these dosages seem wildly exaggerated to me. 100 molecules of harmaline will inhibit 100 molecules of MAO-A, since it must bind with the enzyme. Effective inhibition dose could be calculated by determining the concentration of MOA in the body. Harmine is certainly active at <100mg, and the synergistic property of combined harmala alkaloids as found within Peganum Harmala likely increases their efficacy; two MAO inhibitors will be more effective with less side effects than a higher quantity of one alkaloid alone.
 ==Toxicity and Harm Potential==