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Talk:Dextrorphan: Difference between revisions
>ExistingEntity m Moved erowid user experience thing to the subjective effects section |
>ExistingEntity Added some significant binding affinities to pharmacology section |
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==Pharmacology== | ==Pharmacology== | ||
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> | The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> | ||
===Binding affinities (K<sub>i</sub>)=== | |||
* NMDA antagonist - 486 nM | |||
* Sigma-1 agonist - 351 nM | |||
* Serotonin transporter (SERT) - 484 nM | |||
* Mu opioid agonist - 420 nM | |||
==Subjective effects== | ==Subjective effects== | ||