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'''Dextrorphan''' (also known as '''DXO''') is the main active metabolite of [[dextromethorphan]] ('''DXM'''). DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed.<ref>Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders - 3. Pharmacodynamics (January 2016)[https://www.researchgate.net/publication/292212463_Dextromethorphan_An_update_on_its_utility_for_neurological_and_neuropsychiatric_disorders]</ref> | '''Dextrorphan''' (also known as '''DXO''') is the main active metabolite of [[dextromethorphan]] ('''DXM'''). DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed.<ref>Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders - 3. Pharmacodynamics (January 2016)[https://www.researchgate.net/publication/292212463_Dextromethorphan_An_update_on_its_utility_for_neurological_and_neuropsychiatric_disorders]</ref> | ||