Talk:Dextrorphan: Difference between revisions

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Dextrorphan (DXO) is an active metabolite of [[dextromethorphan]]. ~~This means that~~ DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed.

'''Dextrorphan''' (also known as '''DXO''') is the main active metabolite of [[dextromethorphan]]. DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed.

==Pharmacology==

The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.<ref>

"Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref>

==Subjective effects==

===Physical effects===

*'''[[Effect::Appetite suppression]]'''

*'''[[Effect::Changes in felt bodily form]]'''

*'''[[Effect::Gustatory hallucinations]]'''

*'''[[Effect::Itchiness]]''' - This effect has become subsequently known as "robo-itch" and though relatively common there are many users who never experience this particular effect while some individuals can experience it quite intensely.

*'''[[Effect::Muscle spasms]]'''

*'''[[Motor control loss|Motor control loss]]'''

*'''[[Effect::Pain relief]]'''

*'''[[Effect::Perception of decreased weight]]'''

*'''[[Effect::Physical autonomy]]'''

*'''[[Effect::Spatial disorientation]]'''

*'''[[Effect::Tactile disconnection]]'''

*'''[[Effect::Tactile suppression]]'''

===Cognitive effects===

*'''[[Effect::Amnesia]]'''

*'''[[Effect::Conceptual thinking]]'''

*'''[[Effect::Consciousness disconnection]]'''

*'''[[Effect::Creativity enhancement]]'''

*'''[[Effect::Déjà vu]]'''

*'''[[Effect::Depersonalization]]'''

*'''[[Effect::Derealization]]'''

*'''[[Effect::Disinhibition]]'''

*'''[[Effect::Existential self-realization]]'''

*'''[[Effect::Immersion enhancement]]'''

*'''[[Effect::Increased music appreciation]]'''

*'''[[Effect::Information processing suppression]]'''

*'''[[Effect::Memory suppression]]'''

*'''[[Effect::Novelty enhancement]]'''

*'''[[Effect::Personal bias suppression]]'''

*'''[[Effect::Thought deceleration]]'''

*'''[[Effect::Time distortion]]'''

*'''[[Effect::Unity and interconnectedness]]'''

==See also==

*[[Responsible use]]

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==References==

[[Category:Psychoactive substance]]

[[Category:Morphinan]]

[[Category:Dissociative]]

@@ Line 1: / Line 1: @@
 {{Stub}}
-Dextrorphan (DXO) is an active metabolite of [[dextromethorphan]]. This means that DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed.
+'''Dextrorphan''' (also known as '''DXO''') is the main active metabolite of [[dextromethorphan]]. DXM is metabolized in the body by o-demethylation through the CYP2D6 enzyme to form DXO. Both are active chemicals and contribute to the [[DXM#Subjective effects|subjective effects]] experienced when active doses of DXM are consumed.
+==Pharmacology==
 The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an [[NMDA receptor antagonist]] as well as essentially inactive as a [[serotonin]] [[reuptake inhibitor]].<ref>Psychotropic Effects of Dextromethorphan Are Altered by the CYP2D6 Polymorphism: A Pilot Study [http://journals.lww.com/psychopharmacology/pages/articleviewer.aspx?year=1998&issue=08000&article=00014&type=abstract]</ref> One Erowid user reported excessive itchiness accompanied by a "peaceful yet emotionless state" after 340mg of the substance was consumed.<ref>
 "Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student." Erowid DXM Vault : An Unpleasant Exploration of DXO, by Student. Erowid.org, 15 Sept. 2001. Web. 15 Apr. 2015 [https://www.erowid.org/chemicals/dxm/dxm_info3.shtml]</ref>
+==Subjective effects==
+{{Preamble/SubjectiveEffects}}
+===Physical effects===
+*'''[[Effect::Appetite suppression]]'''
+*'''[[Effect::Changes in felt bodily form]]'''
+*'''[[Effect::Gustatory hallucinations]]'''
+*'''[[Effect::Itchiness]]''' - This effect has become subsequently known as "robo-itch" and though relatively common there are many users who never experience this particular effect while some individuals can experience it quite intensely.
+*'''[[Effect::Muscle spasms]]'''
+*'''[[Motor control loss|Motor control loss]]'''
+*'''[[Effect::Pain relief]]'''
+*'''[[Effect::Perception of decreased weight]]'''
+*'''[[Effect::Physical autonomy]]'''
+*'''[[Effect::Spatial disorientation]]'''
+*'''[[Effect::Tactile disconnection]]'''
+*'''[[Effect::Tactile suppression]]'''
+===Cognitive effects===
+*'''[[Effect::Amnesia]]'''
+*'''[[Effect::Conceptual thinking]]'''
+*'''[[Effect::Consciousness disconnection]]'''
+*'''[[Effect::Creativity enhancement]]'''
+*'''[[Effect::Déjà vu]]'''
+*'''[[Effect::Depersonalization]]'''
+*'''[[Effect::Derealization]]'''
+*'''[[Effect::Disinhibition]]'''
+*'''[[Effect::Existential self-realization]]'''
+*'''[[Effect::Immersion enhancement]]'''
+*'''[[Effect::Increased music appreciation]]'''
+*'''[[Effect::Information processing suppression]]'''
+*'''[[Effect::Memory suppression]]'''
+*'''[[Effect::Novelty enhancement]]'''
+*'''[[Effect::Personal bias suppression]]'''
+*'''[[Effect::Thought deceleration]]'''
+*'''[[Effect::Time distortion]]'''
+*'''[[Effect::Unity and interconnectedness]]'''
 ==See also==
 *[[Responsible use]]
@@ Line 14: / Line 53: @@
 ==References==
 <references />
+[[Category:Psychoactive substance]]
 [[Category:Morphinan]]
 [[Category:Dissociative]]