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JWH-073: Difference between revisions
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JWH-073, unlike many synthetic cannabinoids, is a partial agonist of the CB1 receptors. Because JWH-073 is a partial agonist, unlike most cannabinoids, harm mediated by CB1 receptor agonism can be less severe than its full agonist counterparts. JWH-018 has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids with partial agonism.<ref>Atwood, B.K., et al., "JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist."</ref><ref>http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00582.x/abstract</ref> JWH-073, like other cannabinoids, has also been known to exacerbate pre-existing psychological disorders causing intense paranoia, anxiety and agitation; however, [[Δ9-THC]] itself has been known to do this as well.<ref>http://dx.doi.org/10.1111%2Fj.1360-0443.2010.03119.x</ref> | JWH-073, unlike many synthetic cannabinoids, is a partial agonist of the CB1 receptors. Because JWH-073 is a partial agonist, unlike most cannabinoids, harm mediated by CB1 receptor agonism can be less severe than its full agonist counterparts. JWH-018 has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids with partial agonism.<ref>Atwood, B.K., et al., "JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB1 receptor agonist."</ref><ref>http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00582.x/abstract</ref> JWH-073, like other cannabinoids, has also been known to exacerbate pre-existing psychological disorders causing intense paranoia, anxiety and agitation; however, [[Δ9-THC]] itself has been known to do this as well.<ref>http://dx.doi.org/10.1111%2Fj.1360-0443.2010.03119.x</ref> | ||
