Adrenaline: Difference between revisions

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'''Adrenaline''', also known as '''epinephrine''', is a [[hormone]] and monoamine [[neurotransmitter]]. Adrenaline is primarily produced in the neurones of the central nervous system of animals including humans.  
'''Adrenaline''', also known as '''epinephrine''', is a [[hormone]] and monoamine [[neurotransmitter]]. Adrenaline is primarily produced in the neurones of the central nervous system of animals including humans.  


It is used to regulate heart rate, blood vessel and air passage diameters, and metabolic shifts; adrenaline release is a crucial component of the fight-or-flight response of the sympathetic nervous system.  
It is used to regulate heartrate, blood vessel and air passage diameters, and metabolic shifts. Adrenaline release is a crucial component of the fight-or-flight response of the sympathetic nervous system.  


==Chemistry==
==Chemistry==
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==The Adrenergic System==
==The Adrenergic System==
The adrenergic receptors exhibit both excitatory and inhibitory [[neurone#neurotransmission|neurotransmission]], and are located throughout the human body. There are two types of adrenaline receptors; α<sub>(1 or 2)</sub> and β<sub>(1-3)</sub>.
The adrenergic receptors exhibit both excitatory and inhibitory [[neurone#neurotransmission|neurotransmission]] and are located throughout the human body. There are two types of adrenaline receptors; α<sub>(1 or 2)</sub> and β<sub>(1-3)</sub>.


===Drugs targeting the adrenergic system===
===Drugs targeting the adrenergic system===
*'''Direct-acting Agonists'''
*'''Direct-acting Agonists'''
Many drugs have direct action upon the adrenergic system, where they have action upon the adrenergic receptors themselves. These include antihypertensives (to reduce blood pressure), sedatives and muscle relaxants.
Many drugs have direct action upon the adrenergic system where they have action upon the adrenergic receptors themselves. These include antihypertensives (to reduce blood pressure), sedatives and muscle relaxants.


*'''Indirect-acting Agonists'''
*'''Indirect-acting Agonists'''