Adrenaline: Difference between revisions
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'''Adrenaline''', also known as '''epinephrine''', is a [[hormone]] and monoamine [[neurotransmitter]]. Adrenaline is primarily produced in the neurones of the central nervous system of animals including humans. | '''Adrenaline''', also known as '''epinephrine''', is a [[hormone]] and monoamine [[neurotransmitter]]. Adrenaline is primarily produced in the neurones of the central nervous system of animals including humans. | ||
It is used to regulate | It is used to regulate heartrate, blood vessel and air passage diameters, and metabolic shifts. Adrenaline release is a crucial component of the fight-or-flight response of the sympathetic nervous system. | ||
==Chemistry== | ==Chemistry== | ||
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==The Adrenergic System== | ==The Adrenergic System== | ||
The adrenergic receptors exhibit both excitatory and inhibitory [[neurone#neurotransmission|neurotransmission]] | The adrenergic receptors exhibit both excitatory and inhibitory [[neurone#neurotransmission|neurotransmission]] and are located throughout the human body. There are two types of adrenaline receptors; α<sub>(1 or 2)</sub> and β<sub>(1-3)</sub>. | ||
===Drugs targeting the adrenergic system=== | ===Drugs targeting the adrenergic system=== | ||
*'''Direct-acting Agonists''' | *'''Direct-acting Agonists''' | ||
Many drugs have direct action upon the adrenergic system | Many drugs have direct action upon the adrenergic system where they have action upon the adrenergic receptors themselves. These include antihypertensives (to reduce blood pressure), sedatives and muscle relaxants. | ||
*'''Indirect-acting Agonists''' | *'''Indirect-acting Agonists''' |