Glutamate: Difference between revisions

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'''Glutamate''', also known as '''glutamic acid''', is the most abundant [[neurotransmitter]] in the vertebrate nervous system, and is involved in learning and memory. Glutamate is also used as a precursor in the body for forming [[GABA]], the main inhibitory neurotransmitter.

'''Glutamate''', also known as '''glutamic acid''', is the most abundant [[neurotransmitter]] in the vertebrate nervous system and is involved in learning and memory. Glutamate is also used as a precursor in the body for forming [[GABA]], the main inhibitory neurotransmitter.

==Chemistry==

Glutamate generally exists as a negatively-charged carboxylate, at pH values above 4.

Glutamate generally exists as a negatively-charged carboxylate at pH values above 4.

==The Glutamate System==

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===Drugs targeting the glutamate system===

*'''Agonists'''

A glutamate [[agonist]] is a chemical that binds to and activates a glutamate [[receptor]], and triggers a response, displaying full efficacy at that receptor.

A glutamate [[agonist]] is a chemical that binds to and activates a glutamate [[receptor]] and triggers a response, displaying full efficacy at that receptor.

*'''Positive Allosteric Modulators'''

A positive allosteric modulator is a substance which indirectly influences the effects of an agonist at a receptor, by binding to a site distinct from that of the agonist binding site. Usually they induce a structural change within the receptor structure.

@@ Line 1: / Line 1: @@
-'''Glutamate''', also known as '''glutamic acid''', is the most abundant [[neurotransmitter]] in the vertebrate nervous system, and is involved in learning and memory. Glutamate is also used as a precursor in the body for forming [[GABA]], the main inhibitory neurotransmitter.
+'''Glutamate''', also known as '''glutamic acid''', is the most abundant [[neurotransmitter]] in the vertebrate nervous system and is involved in learning and memory. Glutamate is also used as a precursor in the body for forming [[GABA]], the main inhibitory neurotransmitter.
 ==Chemistry==
-Glutamate generally exists as a negatively-charged carboxylate, at pH values above 4.
+Glutamate generally exists as a negatively-charged carboxylate at pH values above 4.
 ==The Glutamate System==
@@ Line 9: / Line 9: @@
 ===Drugs targeting the glutamate system===
 *'''Agonists'''
-A glutamate [[agonist]] is a chemical that binds to and activates a glutamate [[receptor]], and triggers a response, displaying full efficacy at that receptor.
+A glutamate [[agonist]] is a chemical that binds to and activates a glutamate [[receptor]] and triggers a response, displaying full efficacy at that receptor.
 *'''Positive Allosteric Modulators'''
 A positive allosteric modulator is a substance which indirectly influences the effects of an agonist at a receptor, by binding to a site distinct from that of the agonist binding site. Usually they induce a structural change within the receptor structure.