Harmala alkaloid: Difference between revisions

Line 9:

Harmala alkaloids are selective for MOA-A at reasonable doses and bind to the enzyme temporarily, so they are classed as a [[RIMA|reversible inhibitor of monoamine-A]] ([[RIMA]]). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, harmala alkaloids are considered to be less dangerous in combination with food which contains [[tyramine]] and other substances with monoamine moieties which are reliant on monoamine oxidase for decomposition.

However, it is important to understand that this does not imply that harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and ~~substances~~ which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including [[Sedation|sedation]], [[Stimulation|stimulation]], [[Anxiety|anxiety]], [[cognitive dysphoria]], [[Physical euphoria|euphoria]], [[Headaches|headaches]], [[eye strain]], and [[muscle convulsions]].

However, it is important to understand that this does not imply that harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including [[Sedation|sedation]], [[Stimulation|stimulation]], [[Anxiety|anxiety]], [[cognitive dysphoria]], [[Physical euphoria|euphoria]], [[Headaches|headaches]], [[eye strain]], and [[muscle convulsions]].

Since [[DMT]] is broken down by monoamine oxidase A, inhibition of this enzyme allows for the oral activation of DMT and prolongs the experience for the duration of the harmala alkaloid effects. In combination, harmala alkaloids and DMT are known as [[ayahuasca]].

Line 74:

When intravenously injected into mice, the LD<sub>50</sub> of harmine is 38mg/kg. There is no data for the other harmala alkaloids in humans or animals.

It is strongly recommended that one use [[responsible ~~substance~~ use|harm reduction practices]] when using this drug.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

===Tolerance and addiction potential===

There is no tolerance built up with harmala alkaloid use. There are no real reports of addiction to harmala alkaloids.

@@ Line 9: / Line 9: @@
 Harmala alkaloids are selective for MOA-A at reasonable doses and bind to the enzyme temporarily, so they are classed as a [[RIMA|reversible inhibitor of monoamine-A]] ([[RIMA]]). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, harmala alkaloids are considered to be less dangerous in combination with food which contains [[tyramine]] and other substances with monoamine moieties which are reliant on monoamine oxidase for decomposition.
-However, it is important to understand that this does not imply that harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and substances which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including [[Sedation|sedation]], [[Stimulation|stimulation]], [[Anxiety|anxiety]], [[cognitive dysphoria]], [[Physical euphoria|euphoria]], [[Headaches|headaches]], [[eye strain]], and [[muscle convulsions]].
+However, it is important to understand that this does not imply that harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including [[Sedation|sedation]], [[Stimulation|stimulation]], [[Anxiety|anxiety]], [[cognitive dysphoria]], [[Physical euphoria|euphoria]], [[Headaches|headaches]], [[eye strain]], and [[muscle convulsions]].
 Since [[DMT]] is broken down by monoamine oxidase A, inhibition of this enzyme allows for the oral activation of DMT and prolongs the experience for the duration of the harmala alkaloid effects. In combination, harmala alkaloids and DMT are known as [[ayahuasca]].
@@ Line 74: / Line 74: @@
 When intravenously injected into mice, the LD<sub>50</sub> of harmine is 38mg/kg. There is no data for the other harmala alkaloids in humans or animals.
-It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this drug.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
 ===Tolerance and addiction potential===
 There is no tolerance built up with harmala alkaloid use. There are no real reports of addiction to harmala alkaloids.