Methaqualone: Difference between revisions

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| ''[[Methaqualone/Summary|Summary sheet: Methaqualone]]''

|}'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational ~~drug~~ throughout the world. The ~~drug~~ was popular in the 1970s with hippies and in the disco club scene.

|}'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational substance throughout the world. The substance was popular in the 1970s with hippies and in the disco club scene.

==Chemistry==

Methaqualone, or 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, is a compound of the quinazolinone class. Quinazolinone is a bicyclic structure containing a phenyl ring bound to another six-membered ring with two nitrogen members and a ketone group bound to R4. In methaqualone, this structure is substituted at R2 with a methyl group. Additionally, methaqualone contains a phenyl ring with a methyl group bound to R2 which is attached to the quinazolinone structure at R3.

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===Physical effects===

*'''[[Effect::Sedation]]''' - In terms of energy level alterations, this ~~drug~~ is extremely sedating and often results in an overwhelmingly lethargic state. At higher levels, this causes users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.

*'''[[Effect::Sedation]]''' - In terms of energy level alterations, this substance is extremely sedating and often results in an overwhelmingly lethargic state. At higher levels, this causes users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.

*'''[[Effect::Physical euphoria]]''' - This compound is unusually euphoric in comparison to other compounds within the same class.

*'''[[Effect::Dizziness]]'''

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Although the exact lethal dosage of methaqualone has not been formally established, like many [[depressants]], it is [[Toxicity::safe at appropriate dosages]]. Complications may arise when administered in excess or in combination with other depressants.

It is strongly recommended that one use [[responsible ~~drug~~ use|harm reduction practices]] when using this drug.

It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this drug.

===Tolerance and addiction potential===

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 |-
 | ''[[Methaqualone/Summary|Summary sheet: Methaqualone]]''
-|}'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational drug throughout the world. The drug was popular in the 1970s with hippies and in the disco club scene.
+|}'''Methaqualone''' (brand name '''Quaalude''' in the US and '''Mandrax''' in the UK) is a central nervous system (CNS) [[psychoactive class::depressant]] of the [[chemical class::quinazolinone]] class that acts as a [[sedative]] and [[hypnotic]]. The sedative–hypnotic activity of methaqualone was first noted by researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan.<ref>US Patent 3135659 – Hydroxy and Alkoxy Aryl Quinazolones</ref> Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a [[sedative]] and [[muscle relaxant]]. It is still produced and used clandestinely as a recreational substance throughout the world. The substance was popular in the 1970s with hippies and in the disco club scene.
 ==Chemistry==
 Methaqualone, or 2-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, is a compound of the quinazolinone class. Quinazolinone is a bicyclic structure containing a phenyl ring bound to another six-membered ring with two nitrogen members and a ketone group bound to R<sub>4</sub>. In methaqualone, this structure is substituted at R<sub>2</sub> with a methyl group. Additionally, methaqualone contains a phenyl ring with a methyl group bound to R<sub>2</sub> which is attached to the quinazolinone structure at R<sub>3</sub>.
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 {{Preamble/SubjectiveEffects}}
 ===Physical effects===
-*'''[[Effect::Sedation]]''' -  In terms of energy level alterations, this drug is extremely sedating and often results in an overwhelmingly lethargic state. At higher levels, this causes users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
+*'''[[Effect::Sedation]]''' -  In terms of energy level alterations, this substance is extremely sedating and often results in an overwhelmingly lethargic state. At higher levels, this causes users to suddenly feel as if they are extremely sleep deprived and have not slept for days, forcing them to sit down and generally feel as if they are constantly on the verge of passing out instead of engaging in physical activities. This sense of sleep deprivation increases proportional to dosage and eventually becomes powerful enough to force a person into complete unconsciousness.
 *'''[[Effect::Physical euphoria]]''' - This compound is unusually euphoric in comparison to other compounds within the same class.
 *'''[[Effect::Dizziness]]'''
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 Although the exact lethal dosage of methaqualone has not been formally established, like many [[depressants]], it is [[Toxicity::safe at appropriate dosages]]. Complications may arise when administered in excess or in combination with other depressants.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
+It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this drug.
 ===Tolerance and addiction potential===