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Haloperidol: Difference between revisions
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| ''[[Haloperidol/Summary|Summary sheet: Haloperidol]]'' | | ''[[Haloperidol/Summary|Summary sheet: Haloperidol]]'' | ||
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'''Haloperidol''' (trade name '''Haldol''') is an [[antipsychotic]] | '''Haloperidol''' (trade name '''Haldol''') is an [[antipsychotic]] substance used to treat a variety of mental disorders, such as schizophrenia, [[mania]], bipolar disorder, [[delirium]], [[psychosis]], Tourette syndrome, as well as other symptoms. It was first synthesized in 1958 by Paul Janssen<ref>https://books.google.ca/books?id=Cb6BOkj9fK4C&pg=PA124#v=onepage&q&f=false</ref> from [[meperidine]]<ref>https://books.google.ca/books?id=iDNy0XxGqT8C&pg=PA62#v=onepage&q&f=false</ref>. Haloperidol is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.<ref>http://www.who.int/medicines/publications/essentialmedicines/EML2015_8-May-15.pdf</ref> It is also one of the most frequently prescribed typical antipsychotics and is sometimes carried by medical services as an emergency sedative. | ||
==Chemistry== | ==Chemistry== | ||
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Both typical and atypical antipsychotics can cause tardive dyskinesia.<ref>Tardive dyskinesia and new antipsychotics | http://journals.lww.com/co-psychiatry/pages/articleviewer.aspx?year=2008&issue=03000&article=00012&type=abstract</ref> According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.<ref>Tardive dyskinesia and new antipsychotics | http://journals.lww.com/co-psychiatry/pages/articleviewer.aspx?year=2008&issue=03000&article=00012&type=abstract</ref> Switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.<ref>Tardive Dyskinesia | http://link.springer.com/article/10.1007%2Fs11940-011-0117-x</ref> | Both typical and atypical antipsychotics can cause tardive dyskinesia.<ref>Tardive dyskinesia and new antipsychotics | http://journals.lww.com/co-psychiatry/pages/articleviewer.aspx?year=2008&issue=03000&article=00012&type=abstract</ref> According to one study, rates are lower with the atypicals at 3.9% as opposed to the typicals at 5.5%.<ref>Tardive dyskinesia and new antipsychotics | http://journals.lww.com/co-psychiatry/pages/articleviewer.aspx?year=2008&issue=03000&article=00012&type=abstract</ref> Switching to these atypicals is an option to minimize symptoms of tardive dyskinesia caused by other atypicals.<ref>Tardive Dyskinesia | http://link.springer.com/article/10.1007%2Fs11940-011-0117-x</ref> | ||
It is strongly recommended that one use [[responsible | It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this drug. | ||
==Legal issues== | ==Legal issues== | ||
*'''Australia:''' The | *'''Australia:''' The substance is available via prescription only. | ||
*'''Canada:''' The | *'''Canada:''' The substance is available via prescription only. | ||
*'''United States:''' The | *'''United States:''' The substance is available via prescription only. | ||
*'''United Kingdom:''' Haloperidol is a prescription-only medication. | *'''United Kingdom:''' Haloperidol is a prescription-only medication. | ||