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Methylnaphthidate: Difference between revisions
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| ''[[Methylnaphthidate/Summary|Summary sheet: Methylnaphthidate]]'' | | ''[[Methylnaphthidate/Summary|Summary sheet: Methylnaphthidate]]'' | ||
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'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] | '''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] substance of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD substance [[methylphenidate]] (e.g. ''Ritalin'', ''Focalin'').{{citation needed}} | ||
The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (in a manner similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other, more typical methylphenidate analogs.{{citation needed}} | The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (in a manner similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other, more typical methylphenidate analogs.{{citation needed}} | ||
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{Main|Research chemicals#Toxicity and harm potential}} | {{Main|Research chemicals#Toxicity and harm potential}} | ||
The toxicity and long-term health effects of recreational methylnaphthidate use do not seem to have been studied in any scientific context and the exact toxic and lethal dosages are unknown. This is because methylnaphthidate is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people who have tried methylnaphthidate suggests that there are no negative health effects attributed to simply trying the | The toxicity and long-term health effects of recreational methylnaphthidate use do not seem to have been studied in any scientific context and the exact toxic and lethal dosages are unknown. This is because methylnaphthidate is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people who have tried methylnaphthidate suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com Independent research]should always be done to ensure that a combination of two or more substances is safe before consumption. | ||
It is strongly recommended that one use [[responsible | It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this drug. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
In terms of its tolerance, methylnaphthidate can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects. | In terms of its tolerance, methylnaphthidate can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects. | ||
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==Legal issues== | ==Legal issues== | ||
*'''United Kingdom:''' It is illegal to produce, supply, or import this | *'''United Kingdom:''' It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref> | ||
*'''United States:''' HDMP-28 is not explicitly controlled in the US, but it could possibly be considered an analog of a Schedule II substance (methylphenidate) under the Federal Analog Act. | *'''United States:''' HDMP-28 is not explicitly controlled in the US, but it could possibly be considered an analog of a Schedule II substance (methylphenidate) under the Federal Analog Act. | ||
*'''Switzerland:''' HDMP-28 is illegal in Switzerland as of December 2015.<ref>{{cite web | url=http://web.archive.org/web/20160817151151/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html | title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien | publisher=Der Bundesrat}}</ref> | *'''Switzerland:''' HDMP-28 is illegal in Switzerland as of December 2015.<ref>{{cite web | url=http://web.archive.org/web/20160817151151/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html | title=Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien | publisher=Der Bundesrat}}</ref> | ||