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3-MeO-PCE: Difference between revisions
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'''3-Methoxyeticyclidine''' (abbreviated '''3-MeO-PCE'''; also known as '''Methoxieticyclidine''') is a synthetic [[hallucinogenic]] [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class. | '''3-Methoxyeticyclidine''' (abbreviated '''3-MeO-PCE'''; also known as '''Methoxieticyclidine''') is a synthetic [[hallucinogenic]] [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] class. | ||
Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]]/[[PCE]], [[MXE]] and [[O-PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a moderately higher risk of inducing states of [[delusions]], [[mania]] and [[psychosis]]. Because of this, it is highly recommended to use [[responsible | Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]]/[[PCE]], [[MXE]] and [[O-PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a moderately higher risk of inducing states of [[delusions]], [[mania]] and [[psychosis]]. Because of this, it is highly recommended to use [[responsible substance use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience. | ||
3-MeO-PCE began to gain popularity in 2010 <ref>3-MeO-PCE - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=3-MeO-PCE</ref> and is sold on the online grey area [[research chemical]] market as a legal alternative to [[PCP]] or [[ketamine]].<ref>Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines. | https://www.ncbi.nlm.nih.gov/pubmed/26360516</ref><ref>From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices | 3-MeO-PCE began to gain popularity in 2010 <ref>3-MeO-PCE - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=3-MeO-PCE</ref> and is sold on the online grey area [[research chemical]] market as a legal alternative to [[PCP]] or [[ketamine]].<ref>Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines. | https://www.ncbi.nlm.nih.gov/pubmed/26360516</ref><ref>From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices | ||
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====Enhancements==== | ====Enhancements==== | ||
*'''[[Effect::Bodily control enhancement]]''' and '''[[Motor control loss]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards motor control | *'''[[Effect::Bodily control enhancement]]''' and '''[[Motor control loss]]''' - At lower dosages this compound typically induces enhancements in bodily control. At higher dosages, this enhancement shifts towards motor control | ||
*'''[[Effect::Stimulation]]''' - This | *'''[[Effect::Stimulation]]''' - This substance is extremely stimulating in comparison to other dissociatives such as [[ketamine]], [[MXE]], or [[DCK]]. The stimulation it presents is clean and comfortable in a manner which is far closer to that of [[3-MeO-PCP]] than that of [[O-PCE]]. | ||
====Suppressions==== | ====Suppressions==== | ||
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3-MeO-PCE has been reported to cause [[psychosis]], [[delusions]], and [[mania]] at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug. | 3-MeO-PCE has been reported to cause [[psychosis]], [[delusions]], and [[mania]] at a significantly higher rate than other [[dissociative]]s such as [[ketamine]], [[diphenidine]], or [[MXE]]. There are a large number of experience reports online which describe states of "psychotic delirium, amnesia, mania, and other serious consequences" after abusing the drug. | ||
It is strongly recommended that one use extreme caution and [[responsible | It is strongly recommended that one use extreme caution and [[responsible substance use|harm reduction]] practices when using this substance. | ||
*Users should avoid using the substance multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects. | *Users should avoid using the substance multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects. | ||
*The recommended dosage range should not be exceeded as high doses can trigger these effects as well. | *The recommended dosage range should not be exceeded as high doses can trigger these effects as well. | ||
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*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose. | *[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose. | ||
Due to the risk of psychosis, it is not recommended to combine this | Due to the risk of psychosis, it is not recommended to combine this substance with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | ||
It is strongly recommended that one use [[responsible | It is strongly recommended that one use [[responsible substance use|harm reduction practices]] when using this substance. | ||
===Tolerance and addiction potential=== | ===Tolerance and addiction potential=== | ||
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===Urinary tract effects=== | ===Urinary tract effects=== | ||
Regarding its long-term health effects when used repeatedly and over excessive periods, 3-MeO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because 3-MeO-PCE is far more potent than ketamine, so significantly less of | Regarding its long-term health effects when used repeatedly and over excessive periods, 3-MeO-PCE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because 3-MeO-PCE is far more potent than ketamine, so significantly less of substance needs to be consumed. Symptoms of ketamine-induced cystitis can become severe and can be described as: | ||
*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes. | *'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes. | ||
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==Legal issues== | ==Legal issues== | ||
{{legalStub}} | {{legalStub}} | ||
*'''United Kingdom''' - It is illegal to produce, supply, or import this | *'''United Kingdom''' - It is illegal to produce, supply, or import this substance under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref> | ||
==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||