3-MeO-PCE: Difference between revisions

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| ''[[3-MeO-PCE/Summary|Summary sheet: 3-MeO-PCE]]''

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'''3-MeO-PCE''' (~~abbreviated from~~ '''3-Methoxyeticyclidine''') is a ~~chemical of the~~ [[~~Chemical class::arylcyclohexylamine~~]] ~~class which acts as a~~ [[~~hallucinogenic~~]] [[~~Psychoactive~~ class::~~dissociative~~]]. Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]] and [[PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a ~~notably~~ higher risk of inducing states of ~~[[psychosis]],~~ [[delusions]], ~~and~~ [[mania]]~~, which may make it dangerous to use regardless of the~~ [[~~set and setting~~]]. Because of this, it is highly recommended to use [[responsible drug use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience.

'''3-MeO-PCE''' ('''3-Methoxyeticyclidine'''; also known as '''Methoxieticyclidine''') is a [[hallucinogenic]] [[Psychoactive class::dissociative]] of the [[Chemical class::arylcyclohexylamine]] class. Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]]/[[PCE]], [[MXE]] and [[O-PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a moderately higher risk of inducing states of [[delusions]], [[mania]] and [[psychosis]]. Because of this, it is highly recommended to use [[responsible drug use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience.

3-MeO-PCE began to gain popularity in 2010 <ref>3-MeO-PCE - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=3-MeO-PCE</ref> and is sold on the online grey area [[research chemical]] market as a legal alternative to [[PCP]] or [[ketamine]].<ref>Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines. | https://www.ncbi.nlm.nih.gov/pubmed/26360516</ref><ref>From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices

| http://jat.oxfordjournals.org/content/37/5/277.full</ref><ref>http://nsddb.eu/substance/296/</ref>

==Chemistry==

3-MeO-PCE, or N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, is classed as an [[arylcyclohexylamine]] drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 3-MeO-PCE contains a phenyl ring with a methoxy (CH3-O-) substituent at R3 bonded to a cyclohexane ring. Bound to the same carbon (R1) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3. 3-MeO-PCE, like [[MXE]], contains an amino ethyl chain rather than the amino methyl chain found in [[DCK]] and [[ketamine]]. 3-MeO-PCE is analogous to [[MXE]], but lacks an R2 substituted ketone. It is also homologous to [[3-MeO-PCP]] but lacks the additional carbons to complete a piperidine ring.

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 | ''[[3-MeO-PCE/Summary|Summary sheet: 3-MeO-PCE]]''
 |}
-'''3-MeO-PCE''' (abbreviated from '''3-Methoxyeticyclidine''') is a chemical of the [[Chemical class::arylcyclohexylamine]] class which acts as a [[hallucinogenic]] [[Psychoactive class::dissociative]]. Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]] and [[PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a notably higher risk of inducing states of [[psychosis]], [[delusions]], and [[mania]], which may make it dangerous to use regardless of the [[set and setting]]. Because of this, it is highly recommended to use [[responsible drug use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience.
+'''3-MeO-PCE''' ('''3-Methoxyeticyclidine'''; also known as '''Methoxieticyclidine''') is a [[hallucinogenic]] [[Psychoactive class::dissociative]] of the [[Chemical class::arylcyclohexylamine]] class. Early reports indicate that 3-MeO-PCE shares extremely similar properties to that of [[3-MeO-PCP]] and to a lesser extent, [[PCP]]/[[PCE]], [[MXE]] and [[O-PCE]]<ref>From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs | http://onlinelibrary.wiley.com/doi/10.1002/dta.1620/abstract</ref>, but with what seems to be a moderately higher risk of inducing states of [[delusions]], [[mania]] and [[psychosis]]. Because of this, it is highly recommended to use [[responsible drug use]] practices when using this substance such as using a [[milligram scale]] (and preferably [[volumetric liquid dosing]]) as well as having a sober [[trip sitter]] present throughout the experience.
 -MeO-PCE began to gain popularity in 2010 <ref>3-MeO-PCE - Explore - Google Trends | https://www.google.com/trends/explore?date=all&q=3-MeO-PCE</ref> and is sold on the online grey area [[research chemical]] market as a legal alternative to [[PCP]] or [[ketamine]].<ref>Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines. | https://www.ncbi.nlm.nih.gov/pubmed/26360516</ref><ref>From the Street to the Laboratory: Analytical Profiles of Methoxetamine, 3-Methoxyeticyclidine and 3-Methoxyphencyclidine and their Determination in Three Biological Matrices
   | http://jat.oxfordjournals.org/content/37/5/277.full</ref><ref>http://nsddb.eu/substance/296/</ref>
 ==Chemistry==
 -MeO-PCE, or N-Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine, is classed as an [[arylcyclohexylamine]] drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 3-MeO-PCE contains a phenyl ring with a methoxy (CH<sub>3</sub>-O-) substituent at R<sub>3</sub> bonded to a cyclohexane ring. Bound to the same carbon (R<sub>1</sub>) of the cyclohexanone ring is an amino ethyl chain -NCH<sub>2</sub>CH<sub>3</sub>. 3-MeO-PCE, like [[MXE]], contains an amino ethyl chain rather than the amino methyl chain found in [[DCK]] and [[ketamine]]. 3-MeO-PCE is analogous to [[MXE]], but lacks an R<sub>2</sub> substituted ketone. It is also homologous to [[3-MeO-PCP]] but lacks the additional carbons to complete a piperidine ring.