Methylnaphthidate: Difference between revisions

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| ''[[Methylnaphthidate/Summary|Summary sheet: Methylnaphthidate]]''

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'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] drug of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Focalin'').

'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] drug of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Focalin'').{{citation needed}}

The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other methylphenidate analogs.

The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (in a manner similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other, more typical methylphenidate analogs.{{citation needed}}

Methylnaphthidate has little to no history of human usage prior to its availability by vendors on the online [[research chemical]] market.

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==Pharmacology==

Methylnaphthidate is thought to act primarily as a [[monoamine]] triple [[reuptake inhibitor]], meaning it effectively ~~boosts~~ the levels of [[dopamine]], [[noradrenaline]] and [[serotonin]] [[neurotransmitters]] throughout the brain by binding to and partially blocking the transporter proteins that normally clear these monoamines from the synaptic cleft. This allows these molecules to accumulate throughout the brain, particularly within the reward pathways in the brain, resulting in stimulating and euphoric effects.

Methylnaphthidate is thought to act primarily as a [[monoamine]] triple [[reuptake inhibitor]], meaning it effectively elevates the levels of [[dopamine]], [[noradrenaline]] and [[serotonin]] [[neurotransmitters]] throughout the brain and CNS by binding to and partially blocking the transporter proteins that normally clear out these monoamines from the synaptic cleft. This allows these molecules to accumulate throughout the brain, particularly within the reward pathways in the brain, resulting in stimulating and euphoric effects.

==Subjective effects==

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*'''[[Effect::Dehydration]]'''

*'''[[Effect::Appetite suppression]]'''

*'''[[Effect::Increased heart rate]]''' - This component has been reported by some as being uniquely pronounced in the -phenidate family. These effects might owe themselves to increased free-circulating serotonin in the blood, which would lead to sustained agonism at ~~serotonin~~-2b receptors on the heart.

*'''[[Effect::Increased heart rate]]''' - This component has been reported by some as being uniquely pronounced in the -phenidate family. These effects might owe themselves to increased free-circulating serotonin in the blood, which would lead to sustained agonism at Serotonin-2B receptors on the heart.

*'''[[Effect::Teeth grinding]]''' - This component can be considered to be present, but less intense when compared with that of [[MDMA]].

@@ Line 6: / Line 6: @@
 | ''[[Methylnaphthidate/Summary|Summary sheet: Methylnaphthidate]]''
 |}
-'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] drug of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Focalin'').
+'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] drug of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Focalin'').{{citation needed}}
-The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other methylphenidate analogs.
+The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (in a manner similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other, more typical methylphenidate analogs.{{citation needed}}
 Methylnaphthidate has little to no history of human usage prior to its availability by vendors on the online [[research chemical]] market.
@@ Line 16: / Line 16: @@
 ==Pharmacology==
-Methylnaphthidate is thought to act primarily as a [[monoamine]] triple [[reuptake inhibitor]], meaning it effectively boosts the levels of [[dopamine]], [[noradrenaline]] and [[serotonin]] [[neurotransmitters]] throughout the brain by binding to and partially blocking the transporter proteins that normally clear these monoamines from the synaptic cleft. This allows these molecules to accumulate throughout the brain, particularly within the reward pathways in the brain, resulting in stimulating and euphoric effects.
+Methylnaphthidate is thought to act primarily as a [[monoamine]] triple [[reuptake inhibitor]], meaning it effectively elevates the levels of [[dopamine]], [[noradrenaline]] and [[serotonin]] [[neurotransmitters]] throughout the brain and CNS by binding to and partially blocking the transporter proteins that normally clear out these monoamines from the synaptic cleft. This allows these molecules to accumulate throughout the brain, particularly within the reward pathways in the brain, resulting in stimulating and euphoric effects.
 ==Subjective effects==
@@ Line 26: / Line 26: @@
 *'''[[Effect::Dehydration]]'''
 *'''[[Effect::Appetite suppression]]'''
-*'''[[Effect::Increased heart rate]]''' - This component has been reported by some as being uniquely pronounced in the -phenidate family. These effects might owe themselves to increased free-circulating serotonin in the blood, which would lead to sustained agonism at serotonin-2b receptors on the heart.
+*'''[[Effect::Increased heart rate]]''' - This component has been reported by some as being uniquely pronounced in the -phenidate family. These effects might owe themselves to increased free-circulating serotonin in the blood, which would lead to sustained agonism at Serotonin-2B receptors on the heart.
 *'''[[Effect::Teeth grinding]]''' - This component can be considered to be present, but less intense when compared with that of [[MDMA]].