F-Phenibut: Difference between revisions

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==Pharmacology==

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structural and subjective effect similarities to other [[depressants]] or [[gabapentinoid]] such as [[phenibut]], [[gabapentin]], and [[pregabalin]].

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely speculation based upon its structural and subjective effect similarities to other [[depressants]] or [[gabapentinoid]] such as [[phenibut]], [[gabapentin]], and [[pregabalin]].

Among other things, it is likely that this compound exerts its effects by binding to the α2δ-1 site of voltage-gated calcium channels in a manner which is similar to that of other gabapentinoids. By binding to this site, F-Phenibut may reduce the release of several excitatory [[neurotransmitter]]s, including [[glutamate]], [[substance P]], [[acetylcholine]], and [[norepinephrine]]. This, in turn, increases [[GABA]]ergic activity.{{citation needed}} As the GABA system is the most prevalent inhibitory receptor set within the brain{{citation needed}}, its modulation may be responsible for the relaxing, sedating, and calming effects of F-Phenibut on the central nervous system.

@@ Line 13: / Line 13: @@
 ==Pharmacology==
-Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structural and subjective effect similarities to other [[depressants]] or [[gabapentinoid]] such as [[phenibut]], [[gabapentin]], and [[pregabalin]].
+Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely speculation based upon its structural and subjective effect similarities to other [[depressants]] or [[gabapentinoid]] such as [[phenibut]], [[gabapentin]], and [[pregabalin]].
 Among other things, it is likely that this compound exerts its effects by binding to the α2δ-1 site of voltage-gated calcium channels in a manner which is similar to that of other gabapentinoids. By binding to this site, F-Phenibut may reduce the release of several excitatory [[neurotransmitter]]s, including [[glutamate]], [[substance P]], [[acetylcholine]], and [[norepinephrine]]. This, in turn, increases [[GABA]]ergic activity.{{citation needed}} As the GABA system is the most prevalent inhibitory receptor set within the brain{{citation needed}}, its modulation may be responsible for the relaxing, sedating, and calming effects of F-Phenibut on the central nervous system.