This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Rate-Limiting Step: Difference between revisions
>Simen Created page with "In chemistry, many catalytic reactions have a '''[https://en.wikipedia.org/wiki/Rate-determining_step rate-limiting step]'''. The catalyst is necessary for the reaction to hap..." |
>Simen |
||
| Line 5: | Line 5: | ||
=Prodrugs affected by rate-limiting steps= | =Prodrugs affected by rate-limiting steps= | ||
===[[Codeine]]=== | ===[[Codeine]]=== | ||
Codeine (3-methylmorphine) is a [[prodrug]] for morphine. While codeine has some activity of its own, the vast majority of its pharmacological activity comes from its conversion to morphine. Codeine is metabolized into morphine in the liver by the enzyme enzyme P450 CYP2D6. Too much codeine will saturate these enzymes, leading to a "ceiling effect" around 400mg, where further dosage will not increase blood morphine concentrations. For this reason, codeine is | Codeine (3-methylmorphine) is a [[prodrug]] for morphine. While codeine has some activity of its own, the vast majority of its pharmacological activity comes from its conversion to morphine. Codeine is metabolized into morphine in the liver by the enzyme enzyme P450 CYP2D6. Too much codeine will saturate these enzymes, leading to a "ceiling effect" around 400mg, where further dosage will not increase blood morphine concentrations. For this reason, codeine is '''relatively'' safe in overdose compared to other opiates, which is not to say that caution isn't warranted. | ||
===[[Lisdexamfetamine]]=== | ===[[Lisdexamfetamine]]=== | ||