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A-PHP: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
α-PHP is a substituted hexanone bound to a phenyl ring and a pyrrolidine ring. It is a stimulant of the [[monoamine]] cathinone class, similar to pentedrone. α-PHP shares a similar structure to a phenethylamine core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain. It is substituted at R<sub>α</sub> with a butyl chain. Additionally it features an oxygen substitution double-bonded to R<sub>β</sub>. | α-PHP is a substituted hexanone bound to a phenyl ring and a pyrrolidine ring. It is a stimulant of the [[monoamine]] cathinone class, similar to pentedrone. α-PHP shares a similar structure to a phenethylamine core featuring a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain. It is substituted at R<sub>α</sub> with a butyl chain. Additionally, it features an oxygen substitution double-bonded to R<sub>β</sub>. | ||
α-PHP is the longer chain | α-PHP is the longer chain homolog of α-PVP, possessing an additional carbon on the alkyl side chain. | ||
==Pharmacology== | ==Pharmacology== | ||
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==Subjective effects== | ==Subjective effects== | ||
In comparison to its predecessor ([[A-PVP]]), this compound induces considerably less anxiety, uncomfortable side effects, euphoria and psychosis. | In comparison to its predecessor ([[A-PVP]]), this compound induces considerably less anxiety, uncomfortable side effects, euphoria, and psychosis. | ||
The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. | The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. | ||
These are described below and | These are described below and include: | ||
===Physical effects=== | ===Physical effects=== | ||
*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of α-PHP can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelming at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. | *'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of α-PHP can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelming at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. | ||
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===Cognitive effects=== | ===Cognitive effects=== | ||
The cognitive effects of α-PHP can be broken down into several components which progressively intensify proportional to dosage. The | The cognitive effects of α-PHP can be broken down into several components which progressively intensify proportional to dosage. The ample head space of α-PHP is described by many as one of extreme mental stimulation and great euphoria. It contains a large number of typical [[Stimulants|stimulant]] cognitive effects. | ||
The most prominent of these cognitive effects generally include: | The most prominent of these cognitive effects generally include: | ||
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
{{Main|Research chemicals#Toxicity and harm potential}} | {{Main|Research chemicals#Toxicity and harm potential}} | ||
The toxicity and long-term health effects of recreational α-PHP use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because α-PHP has very little history of human usage. Anecdotal evidence from people who have tried α-PHP within the community | The toxicity and long-term health effects of recreational α-PHP use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because α-PHP has very little history of human usage. Anecdotal evidence from people who have tried α-PHP within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). | ||
α-PHP has been reported to be the cause, or a significant contributory cause, of death in suicides and overdoses caused by combinations of drugs.<ref>Suicide attempt with a mix of [[synthetic cannabinoids]] and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alphA-PHP and 4-CMC (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0379073816000372</ref> | α-PHP has been reported to be the cause, or a significant contributory cause, of death in suicides and overdoses caused by combinations of drugs.<ref>Suicide attempt with a mix of [[synthetic cannabinoids]] and synthetic cathinones: Case report of non-fatal intoxication with AB-CHMINACA, AB-FUBINACA, alpha-PHP, alphA-PHP, and 4-CMC (ScienceDirect) | http://www.sciencedirect.com/science/article/pii/S0379073816000372</ref> | ||
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug. | It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug. | ||