Methoxetamine: Difference between revisions

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MXE acts as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].”

MXE also acts as a [[serotonin]]-[[Reuptake Inhibitor|reuptake inhibitor]]<ref>https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/119087/methoxetamine2012.pdf</ref> and a [[dopamine]] [[reuptake inhibitor]] with ~~alleged~~ [[Opioid receptors|µ-opioid]] affinity and typical [[Dissociatives#Subjective effects|dissociative]] effects. This provides an explanation for its euphoric and often stimulating effects.

MXE also acts as a [[serotonin]]-[[Reuptake Inhibitor|reuptake inhibitor]]<ref>https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/119087/methoxetamine2012.pdf</ref> and a [[dopamine]] [[reuptake inhibitor]] with unsubstantiated claims of [[Opioid receptors|µ-opioid]] affinity and typical [[Dissociatives#Subjective effects|dissociative]] effects. This provides an explanation for its euphoric and often stimulating effects.

==Subjective effects==

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 MXE acts as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “[http://en.wikipedia.org/wiki/K-hole k-hole].”
-MXE also acts as a [[serotonin]]-[[Reuptake Inhibitor|reuptake inhibitor]]<ref>https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/119087/methoxetamine2012.pdf</ref> and a [[dopamine]] [[reuptake inhibitor]] with alleged [[Opioid receptors|µ-opioid]] affinity and typical [[Dissociatives#Subjective effects|dissociative]] effects. This provides an explanation for its euphoric and often stimulating effects.
+MXE also acts as a [[serotonin]]-[[Reuptake Inhibitor|reuptake inhibitor]]<ref>https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/119087/methoxetamine2012.pdf</ref> and a [[dopamine]] [[reuptake inhibitor]] with unsubstantiated claims of [[Opioid receptors|µ-opioid]] affinity and typical [[Dissociatives#Subjective effects|dissociative]] effects. This provides an explanation for its euphoric and often stimulating effects.
 ==Subjective effects==