Modafinil: Difference between revisions

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==Pharmacology==

Research suggests that Modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects. <ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil ~~also~~

Research suggests that Modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects. <ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil has recently been shown to act as an uptake inhibitor for the neurotransmitter [[dopamine]], evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission. <ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref>

~~The reported nondopaminergic effects of modafinil include activation of α1 adrenergic receptors (Duteil et al.~~, ~~1990), enhancement~~ of ~~serotonin (5-HT) function (Ferraro et al., 2000), inhibition of GABA release (Ferraro et al., 1997, 1998), and stimulation of glutamate~~ and ~~histamine release (Ferraro et al., 1999; Ishizuka et al., 2003)~~.

<ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref>

~~Modafinil seems to inhibit the reuptake action of the dopamine transporter, thus leading to an increase in extracellular and thus synaptic concentrations of dopamine.[103]~~

~~Modafinil seems to inhibit the reuptake action of the dopamine transporter, thus leading to an increase in extracellular and thus synaptic concentrations of dopamine~~

==Subjective effects==

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 ==Pharmacology==
-Research suggests that Modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects. <ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil also
+Research suggests that Modafinil increases hypothalamic histamine levels in the brains of rats, which may contribute to its locomotor effects. <ref>European Journal of Pharmacology - Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats | http://www.sciencedirect.com/science/article/pii/S001429990701031X</ref> Modafinil has recently been shown to act as an uptake inhibitor for the neurotransmitter [[dopamine]], evidently leading to increased extraceullular concentrations of dopamine and dopaminergic neurotransmission. <ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref>
-The reported nondopaminergic effects of modafinil include activation of α1 adrenergic receptors (Duteil et al., 1990), enhancement of serotonin (5-HT) function (Ferraro et al., 2000), inhibition of GABA release (Ferraro et al., 1997, 1998), and stimulation of glutamate and histamine release (Ferraro et al., 1999; Ishizuka et al., 2003).
-<ref>The Journal of Pharmacology and Experimental Therapeutics - Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672878</ref>
- Modafinil seems to inhibit the reuptake action of the dopamine transporter, thus leading to an increase in extracellular and thus synaptic concentrations of dopamine.[103]
-Modafinil seems to inhibit the reuptake action of the dopamine transporter, thus leading to an increase in extracellular and thus synaptic concentrations of dopamine
 ==Subjective effects==