MDPV: Difference between revisions

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Incidents of psychological and physical harm have been attributed to MDPV use.

==Chemistry==

MDPV, or 3,4-Methylenedioxypyrovalerone, is a cathinone-class stimulant. Specifically, MDPV possesses a 2-amino-1-phenylpropan-1-one nucleus. Many, but not all, cathinone-based substances also possess this nucleus. Cathinone, and by extension MDPV, differs from most stimulants due it containing a ketone functional group.

==Pharmacology==

MDPV acts as a [[Noradrenalin|norepinephrine]]-[[dopamine]] [[reuptake inhibitor]]. Reduced re-uptake of the main [[neurotransmitter]]s norepinephrine and dopamine results in higher concentrations of the two in the [[Synapse|synapse]], or junction between [[Neurons|neurons]]. The result of this inhibition is an enhanced and prolonged post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. [[Serotonin]] transmitters also experience a similar effect, although to a much lesser degree. This sudden increase in neurotransmitter levels in the brain is responsible for the high that MDPV provides. Mainly possessing re-uptake inhibiting qualities, MDPV could be considered more like [[cocaine]] in method of action than amphetamine, which works primarily as an agonist to release dopamine and noradrenalin.<ref>http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1</ref>

==Subjective effects==

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

[[Category:Proofread]][[Category:Approval]]

@@ Line 10: / Line 10: @@
 Incidents of psychological and physical harm have been attributed to MDPV use.
+==Chemistry==
+MDPV, or 3,4-Methylenedioxypyrovalerone, is a cathinone-class stimulant. Specifically, MDPV possesses a 2-amino-1-phenylpropan-1-one  nucleus. Many, but not all, cathinone-based substances also possess this nucleus. Cathinone, and by extension MDPV, differs from most stimulants due it containing a ketone functional group.
+==Pharmacology==
+MDPV acts as a [[Noradrenalin|norepinephrine]]-[[dopamine]] [[reuptake inhibitor]]. Reduced re-uptake of the main [[neurotransmitter]]s norepinephrine and dopamine results in higher concentrations of the two in the [[Synapse|synapse]], or junction between [[Neurons|neurons]]. The result of this inhibition is an enhanced and prolonged post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. [[Serotonin]] transmitters also experience a similar effect, although to a much lesser degree. This sudden increase in neurotransmitter levels in the brain is responsible for the high that MDPV provides. Mainly possessing re-uptake inhibiting qualities, MDPV could be considered more like [[cocaine]] in method of action than amphetamine, which works primarily as an agonist to release dopamine and noradrenalin.<ref>http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1</ref>
+==Subjective effects==
+The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
 [[Category:Proofread]][[Category:Approval]]