A-PHP: Difference between revisions

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| ''[[A-PHP/Summary|Summary sheet: A-PHP]]''

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'''α-PHP''' (also known as '''A-PHP''', '''alpha-PHP''', '''α-Pyrrolidinohexanophenone''', or '''PV-7''') is a synthetic [[psychoactive class::stimulant]] drug of the [[chemical class::cathinone]] and [[pyrovalerone]] classes. It is chemically similar to other pyrovalerone compounds such as [[MDPV]] ~~and~~ [[cathinone]] derivatives ~~like~~ [[A-PVP]]. It generally comes in the form of either a crystalline powder or ~~crystallized~~ shards which users can ingest to produce short-lived euphoric stimulant effects which are somewhat similar to those of [[methamphetamine]] and [[cocaine]] when [[insufflated]] or [[vaporized]].

'''α-PHP''' (also known as '''A-PHP''', '''alpha-PHP''', '''α-Pyrrolidinohexanophenone''', or '''PV-7''') is a synthetic [[psychoactive class::stimulant]] drug of the [[chemical class::cathinone]] and [[pyrovalerone]] classes. It is chemically similar to other pyrovalerone compounds such as [[MDPV]] as well as previous [[designer drug]] [[cathinone]] derivatives such as [[A-PVP]]. It generally comes in the form of either a crystalline powder or crystal shards which users can ingest to produce short-lived euphoric stimulant effects which are somewhat similar to those of [[methamphetamine]] and [[cocaine]] when [[insufflated]] or [[vaporized]].

α-PHP has a short history of use and is subject to much scrutiny by the media, similar to how MDPV and "bath salts" were portrayed in early 2011 and α-PVP (or '''flakka''') a few years later, where it has replaced it in many parts of the world. It is typically mass produced in Chinese laboratories and sold as a [[research chemical]] through online vendors.

α-PHP has a short history of use and is subject to much scrutiny by the media, similar to how MDPV and "bath salts" were portrayed in early 2011 and α-PVP (known on the street as '''flakka''') a few years later, where it has replaced it in many parts of the world. It is typically mass produced in Chinese laboratories and sold as a [[research chemical]] through online vendors.

==Chemistry==

α-PHP is a substituted hexanone bound to a phenyl ring and a pyrrolidine ring. It is a stimulant of the [[monoamine]] cathinone class, similar to pentedrone. α-PHP shares a similar structure to a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. It is substituted at R<sub>α</sub> with a butyl chain. Additionally it features an oxygen substitution double-bonded to R<sub>β</sub>.

α-PHP is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain.

==Pharmacology==

The mechanism of action is unknown for α-PHP. Aside from a substantially shorter duration, it is believed to act similarly to the [[designer drug]] MDPV, which acts as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI),<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602954</ref> although no substantial research on the pharmacology of this compound has been conducted.

The mechanism of action is unknown for α-PHP. Aside from a substantially shorter duration, it is believed to act similarly to the [[designer drug]] MDPV, which acts as a potent [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI),<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602954</ref> although no substantial research on the pharmacology of this compound has been conducted.

==Subjective effects==

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 | ''[[A-PHP/Summary|Summary sheet: A-PHP]]''
 |}
-'''α-PHP''' (also known as '''A-PHP''', '''alpha-PHP''', '''α-Pyrrolidinohexanophenone''', or '''PV-7''') is a synthetic [[psychoactive class::stimulant]] drug of the [[chemical class::cathinone]] and [[pyrovalerone]] classes. It is chemically similar to other pyrovalerone compounds such as [[MDPV]] and [[cathinone]] derivatives like [[A-PVP]]. It generally comes in the form of either a crystalline powder or crystallized shards which users can ingest to produce short-lived euphoric stimulant effects which are somewhat similar to those of [[methamphetamine]] and [[cocaine]] when [[insufflated]] or [[vaporized]].
+'''α-PHP''' (also known as '''A-PHP''', '''alpha-PHP''', '''α-Pyrrolidinohexanophenone''', or '''PV-7''') is a synthetic [[psychoactive class::stimulant]] drug of the [[chemical class::cathinone]] and [[pyrovalerone]] classes. It is chemically similar to other pyrovalerone compounds such as [[MDPV]] as well as previous [[designer drug]] [[cathinone]] derivatives such as [[A-PVP]]. It generally comes in the form of either a crystalline powder or crystal shards which users can ingest to produce short-lived euphoric stimulant effects which are somewhat similar to those of [[methamphetamine]] and [[cocaine]] when [[insufflated]] or [[vaporized]].
-α-PHP has a short history of use and is subject to much scrutiny by the media, similar to how MDPV and "bath salts" were portrayed in early 2011 and α-PVP (or '''flakka''') a few years later, where it has replaced it in many parts of the world. It is typically mass produced in Chinese laboratories and sold as a [[research chemical]] through online vendors.
+α-PHP has a short history of use and is subject to much scrutiny by the media, similar to how MDPV and "bath salts" were portrayed in early 2011 and α-PVP (known on the street as '''flakka''') a few years later, where it has replaced it in many parts of the world. It is typically mass produced in Chinese laboratories and sold as a [[research chemical]] through online vendors.
 ==Chemistry==
 α-PHP is a substituted hexanone bound to a phenyl ring and a pyrrolidine ring. It is a stimulant of the [[monoamine]] cathinone class, similar to pentedrone. α-PHP shares a similar structure to a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. It is substituted at R<sub>α</sub> with a butyl chain. Additionally it features an oxygen substitution double-bonded to R<sub>β</sub>.
+α-PHP is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain.
 ==Pharmacology==
-The mechanism of action is unknown for α-PHP. Aside from a substantially shorter duration, it is believed to act similarly to the [[designer drug]] MDPV, which acts as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI),<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602954</ref> although no substantial research on the pharmacology of this compound has been conducted.
+The mechanism of action is unknown for α-PHP. Aside from a substantially shorter duration, it is believed to act similarly to the [[designer drug]] MDPV, which acts as a potent [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI),<ref>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602954</ref> although no substantial research on the pharmacology of this compound has been conducted.
 ==Subjective effects==