SAM-e: Difference between revisions

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A review of trials assessing oral doses of SAMe between 200mg and 1600mg notes that they appear to have similar efficacy to Tricyclic Antidepressants and more effective than placebo.<ref>A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. | http://www.ncbi.nlm.nih.gov/pubmed/20191258</ref>

==Chemistry==

~~{{chemistry}}~~

S-adenosyl methionine is a molecule, found endogenously as a substrate synthesized by the sub-groups adenosine and methionine through an the enzyme methionine adenosyltransferase. The adenosine subcomponent is comprised of an adedine nucleobase bonded to a ribose chain. This ribose chain is attached to the terminal carbon of the methionine group. Methionine is a butyl carboxylic acid substituted at R<sub>2</sub> with an amino group and at R<sub>4</sub> with a methylthio (carbon-sulphur) group. S-adenosyl methionine is an essential methyl donator in metabolic reactions.

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 A review of trials assessing oral doses of SAMe between 200mg and 1600mg notes that they appear to have similar efficacy to Tricyclic Antidepressants and more effective than placebo.<ref>A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. | http://www.ncbi.nlm.nih.gov/pubmed/20191258</ref>
 ==Chemistry==
-{{chemistry}}
 S-adenosyl methionine is a molecule, found endogenously as a substrate synthesized by the sub-groups adenosine and methionine through an the enzyme methionine adenosyltransferase. The adenosine subcomponent is comprised of an adedine nucleobase bonded to a ribose chain. This ribose chain is attached to the terminal carbon of the methionine group. Methionine is a butyl carboxylic acid substituted at R<sub>2</sub> with an amino group and at R<sub>4</sub> with a methylthio (carbon-sulphur) group. S-adenosyl methionine is an essential methyl donator in metabolic reactions.