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 ==Chemistry==
 {{chemistry}}
+S-adenosyl methionine is a molecule, found endogenously as a substrate synthesized by the sub-groups adenosine and methionine through an the enzyme methionine adenosyltransferase.
-S-Adenosyl methionine is a cofactor whose structure features an adenosine group bonded to the sulfur of methionine. In the biosynthesis of S-adenosyl methionine, methionine (the nucleophile) displaces triphosphate (the leaving group) from ATP (the electrophile). This is an enzyme-mediated reaction, making Sam-e chemically similar to both ATP and Methionine. <ref>Illustrated Glossary of Organic Chemistry S-adenosyl methionine (SAM) | http://www.chem.ucla.edu/~harding/IGOC/S/sam.html</ref>
 ==Pharmacology==