25x-NBOMe: Difference between revisions

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[[File:25x-NBOMe.png|301px|thumbnail|The general structure for a 25x-NBOMe compound]]

'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series ~~has~~ nearly no history of human use ~~prior to~~ 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.

'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.

It is often sold as [[LSD]], but one ~~key~~ difference between 25x-NBOMe and [[LSD]] is that NBOMe is only active when taken through a sublingual or insufflated route. This means that ~~in order~~ to get the full effects, 25x-NBOMe blotter paper must be lightly chewed on for 20+ minutes and never immediately swallowed. 25x-NBOMe blotters have a distinct taste that [[LSD]] blotters do not have. Insufflation, however, is not recommended; reports of people suffering dangerous and often fatal overdoses due to this route of administration have been surfacing.

It is often sold as [[LSD]], but one fundamental difference between 25x-NBOMe and [[LSD]] is that NBOMe is only active when taken through a sublingual or insufflated route. This means that to get the full effects, 25x-NBOMe blotter paper must be lightly chewed on for 20+ minutes and never immediately swallowed. 25x-NBOMe blotters have a distinct taste that [[LSD]] blotters do not have. Insufflation, however, is not recommended; reports of people suffering dangerous and often fatal overdoses due to this route of administration have been surfacing.

==Chemistry==

In a comparison of 25x-NBOMe and [[2C-x]] chemicals, each 25x-NBOMe molecule is a serotonergic N-benzyl derivative of the corresponding [[2C-x]] molecule. This change in structure results in an increase in potency. It differs from the ~~corresponding~~ 2C-x structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. The addition of this BOMe group also causes most of the compounds to have relatively the same duration, regardless of how long the 2C-x counterpart lasts.

In a comparison of 25x-NBOMe and [[2C-x]] chemicals, each 25x-NBOMe molecule is a serotonergic N-benzyl derivative of the corresponding [[2C-x]] molecule. This change in structure results in an increase in potency. It differs from the related 2C-x structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. The addition of this BOMe group also causes most of the compounds to have relatively the same duration, regardless of how long the 2C-x counterpart lasts.

==Examples==

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==Health effects, potential addiction and tolerance==

The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective [[serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants]] ~~in general~~ to avoid [[serotonin syndrome]], a potentially life-threatening condition in which an abundance of serotonin ~~is built~~ up the body, ~~causing many physical and cognitive health problems~~.

The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective [[serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants]]. This helps to avoid [[serotonin syndrome]], a potentially life-threatening condition in which an abundance of serotonin builds up in the body, which in some cases can be fatal.

==Legal issues==

@@ Line 1: / Line 1: @@
 {{Warning/25x-NBOMe}}
 [[File:25x-NBOMe.png|301px|thumbnail|The general structure for a 25x-NBOMe compound]]
-'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series has nearly no history of human use prior to 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.
+'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.
-It is often sold as [[LSD]], but one key difference between 25x-NBOMe and [[LSD]] is that NBOMe is only active when taken through a sublingual or insufflated route. This means that in order to get the full effects, 25x-NBOMe blotter paper must be lightly chewed on for 20+ minutes and never immediately swallowed. 25x-NBOMe blotters have a distinct taste that [[LSD]] blotters do not have. Insufflation, however, is not recommended; reports of people suffering dangerous and often fatal overdoses due to this route of administration have been surfacing.
+It is often sold as [[LSD]], but one fundamental difference between 25x-NBOMe and [[LSD]] is that NBOMe is only active when taken through a sublingual or insufflated route. This means that to get the full effects, 25x-NBOMe blotter paper must be lightly chewed on for 20+ minutes and never immediately swallowed. 25x-NBOMe blotters have a distinct taste that [[LSD]] blotters do not have. Insufflation, however, is not recommended; reports of people suffering dangerous and often fatal overdoses due to this route of administration have been surfacing.
 ==Chemistry==
-In a comparison of 25x-NBOMe and [[2C-x]] chemicals, each 25x-NBOMe molecule is a serotonergic N-benzyl derivative of the corresponding [[2C-x]] molecule. This change in structure results in an increase in potency. It differs from the corresponding 2C-x structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. The addition of this BOMe group also causes most of the compounds to have relatively the same duration, regardless of how long the 2C-x counterpart lasts.
+In a comparison of 25x-NBOMe and [[2C-x]] chemicals, each 25x-NBOMe molecule is a serotonergic N-benzyl derivative of the corresponding [[2C-x]] molecule. This change in structure results in an increase in potency. It differs from the related 2C-x structurally through a substitution on the amine (NH2) with a 2-methoxybenzyl (BOMe) group. The addition of this BOMe group also causes most of the compounds to have relatively the same duration, regardless of how long the 2C-x counterpart lasts.
 ==Examples==
@@ Line 31: / Line 31: @@
 ==Health effects, potential addiction and tolerance==
-The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective [[serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants]] in general to avoid [[serotonin syndrome]], a potentially life-threatening condition in which an abundance of serotonin is built up the body, causing many physical and cognitive health problems.
+The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective [[serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants]]. This helps to avoid [[serotonin syndrome]], a potentially life-threatening condition in which an abundance of serotonin builds up in the body, which in some cases can be fatal.
 ==Legal issues==