SAM-e: Difference between revisions

S-Adenosyl methionine is a cofactor whose structure features an adenosine group bonded to the sulfur of methionine. A biological methylator. In the biosynthesis of S-adenosyl methionine, methionine (the nucleophile) displaces triphosphate (the leaving group) from ATP (the electrophile). This is an enzyme-mediated reaction, making Sam-e chemically similar to both ATP and Methionine. <ref>Illustrated Glossary of Organic Chemistry S-adenosyl methionine (SAM) | http://www.chem.ucla.edu/~harding/IGOC/S/sam.html</ref>