Harmala alkaloid: Difference between revisions

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==Toxicity and harm potential==

===Drug interactions===

While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medication, certain herbs, most cold medicine (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc.~~<ref>Reversible inhibitor of monoamine oxidase A - Wikipedia, https://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A (accessed November 22, 2016).</ref>~~ Sedatives are likely easier tolerated, but potentiation should be expected.

While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs.<ref>Reversible inhibitor of monoamine oxidase A - Wikipedia, https://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A (accessed November 22, 2016).</ref> In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medication, certain herbs, most cold medicine (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc. Sedatives are likely easier tolerated, but potentiation should be expected.

===Lethal dosage===

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 ==Toxicity and harm potential==
 ===Drug interactions===
-While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs. In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medication, certain herbs, most cold medicine (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc.<ref>Reversible inhibitor of monoamine oxidase A - Wikipedia, https://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A (accessed November 22, 2016).</ref> Sedatives are likely easier tolerated, but potentiation should be expected.
+While safer than general [[MAOIs]], RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs.<ref>Reversible inhibitor of monoamine oxidase A - Wikipedia, https://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A (accessed November 22, 2016).</ref> In particular, they can cause [[serotonin syndrome]] or hypertensive crisis when combined with almost any [[antidepressant]], [[stimulant]], common migraine medication, certain herbs, most cold medicine (including decongestants, [[antihistamines]], and cough syrup), nicotine, caffeine, etc. Sedatives are likely easier tolerated, but potentiation should be expected.
 ===Lethal dosage===