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Modafinil: Difference between revisions
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*'''[[Physical effects: Headaches|Headaches]]''' | *'''[[Physical effects: Headaches|Headaches]]''' | ||
*'''[[Physical effects: Photophobia|Photophobia]]''' | *'''[[Physical effects: Photophobia|Photophobia]]''' | ||
*'''[[Physical effects: Nausea|Nausea]]''' | |||
===Cognitive Effects=== | ===Cognitive Effects=== | ||
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===Lethal Dosage=== | ===Lethal Dosage=== | ||
The median lethal dose at which 50% of participants die (LD50) from Modafinil for human beings has never been reached. No life-threatening effects have taken place in clinical trials involving the administration of 1000mg to 1600mg of Modafinil per day for 7 to 21 consecutive days. Intentional acute overdoses of 4500mg and 4000mg in two adult subjects and an accidental injestion of 800mg by a three-year-old child did not result in any life-threatening effects or death. <ref>The National Library of Medicine - PROVIGIL | http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fd75a8a7-a8ab-4141-9af9-989a220b9c19</ref> After overdosing on 5000mg of Modafinil in a suicide attempt, a fifteen-year-old female reported a severe [[Physical effects: Headaches|headache]], [[Physical effects: Nausea|nausea]], and [[Physical effects: Abnormal heartbeat|tachycardia]], but did not appear to have any lethan or long-term effects. <ref>Journal of Clinical Sleep Medicine - Unsuccessful Suicide Attempt of a 15 Year Old Adolescent with Ingestion of 5000 mg Modafinilhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725258</ref> | |||
===Tolerance and Addiction Potential=== | ===Tolerance and Addiction Potential=== | ||