Pethidine: Difference between revisions

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Pethidine has a [[Toxicity::high toxicity]] relative to dose. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]] and generally has a wider range of substances which it is [[pethidine#Dangerous interactions|dangerous to combine with]] in comparison to other opioids.

One of pethdine's metabolites, norpethidine has little to no opioid action, but is know to cause seizures. Pethidine should not be taken during [[Benzodiazepine#Discontinuation|benzodiazepine withdrawals]] as this can potentially cause [[seizure]]s. In 1984, Libby Zion, a teenager was brought to the emergency room due to a "flu-like" ailment. She was previously prescribed and taking phenelzine, a [[MAOI |monoamine oxidase inhibitor]], which in combination caused fatal serotonin syndrome.

One of pethdine's metabolites, norpethidine has little to no opioid action, but is know to cause seizures. Pethidine should not be taken during [[Benzodiazepine#Discontinuation|benzodiazepine withdrawals]] as this can potentially cause [[seizure]]s. In 1984, Libby Zion, a teenager was brought to the emergency room due to a "flu-like" ailment. She was previously prescribed and taking phenelzine, a [[MAOI |monoamine oxidase inhibitor]], which in combination caused fatal serotonin syndrome.<ref> Serotonin Syndrome and the Libby Zion Affair | http://epmonthly.com/article/serotonin-syndrome-and-the-libby-zion-affair/ </ref>

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.

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 Pethidine has a [[Toxicity::high toxicity]] relative to dose. As with all opioids, long-term effects can vary but can include diminished libido, apathy and memory loss. It is also [[Toxicity::potentially [[respiratory depression|lethal]] when mixed with [[depressants]] like [[alcohol]] or [[benzodiazepines]]]] and generally has a wider range of substances which it is [[pethidine#Dangerous interactions|dangerous to combine with]] in comparison to other opioids.
-One of pethdine's metabolites, norpethidine has little to no opioid action, but is know to cause seizures. Pethidine should not be taken during [[Benzodiazepine#Discontinuation|benzodiazepine withdrawals]] as this can potentially cause [[seizure]]s. In 1984, Libby Zion, a teenager was brought to the emergency room due to a "flu-like" ailment. She was previously prescribed and taking phenelzine, a [[MAOI |monoamine oxidase inhibitor]], which in combination caused fatal serotonin syndrome.
+One of pethdine's metabolites, norpethidine has little to no opioid action, but is know to cause seizures. Pethidine should not be taken during [[Benzodiazepine#Discontinuation|benzodiazepine withdrawals]] as this can potentially cause [[seizure]]s. In 1984, Libby Zion, a teenager was brought to the emergency room due to a "flu-like" ailment. She was previously prescribed and taking phenelzine, a [[MAOI |monoamine oxidase inhibitor]], which in combination caused fatal serotonin syndrome.<ref> Serotonin Syndrome and the Libby Zion Affair | http://epmonthly.com/article/serotonin-syndrome-and-the-libby-zion-affair/ </ref>
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.