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The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include: | The effects which occur during the [[offset]] of a [[stimulant]] experience generally feel negative and uncomfortable in comparison to the effects which occurred during its [[peak]]. This is often referred to as a "comedown" and occurs because of [[neurotransmitter]] depletion. Its effects commonly include: | ||
*'''[[Effect::Anxiety]]''' | *'''[[Effect::Anxiety]]''' | ||
*'''[[Effect::Headaches]]''' | |||
*'''[[Effect::Cognitive fatigue]]''' | *'''[[Effect::Cognitive fatigue]]''' | ||
*'''[[Effect::Depression]]''' | *'''[[Effect::Depression]]''' | ||
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*'''[[Effect::Wakefulness]]''' | *'''[[Effect::Wakefulness]]''' | ||
It should be noted that many users have described the comedown of ethyl-pentedrone as being particularly “smooth,” so these effects may not be present to as great a degree as other stimulants. | It should be noted that many users have described the comedown of ethyl-pentedrone as being particularly “smooth,” so these effects may not be present to as great a degree as other stimulants. | ||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||