4F-MPH: Difference between revisions

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'''4F-MPH''' ('''4'-fluoro-methylphenidate''') is a [[stimulant]] of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (Ritalin, Focalin). The two substances are believed to have very similar pharmacological mechanisms but have been reported to display distinctive subjective effects, with 4F-MPH being considered significantly more euphoric and recreational, perhaps owing to the fact that it has been shown to act as a higher efficiency [[dopamine]] reuptake inhibitor than the parent compound methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>

4F-MPH has little to no history of human usage prior to its availability on the [[research chemical]] market. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 due to a temporary blanket ban, which later became permanent. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>

4F-MPH has little to no history of human usage prior to its availability by vendors on the online [[research chemical]] market. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 due to a temporary blanket ban, which later became permanent. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>

==Chemistry==

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 '''4F-MPH''' ('''4'-fluoro-methylphenidate''') is a [[stimulant]] of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (Ritalin, Focalin). The two substances are believed to have very similar pharmacological mechanisms but have been reported to display distinctive subjective effects, with 4F-MPH being considered significantly more euphoric and recreational, perhaps owing to the fact that it has been shown to act as a higher efficiency [[dopamine]] reuptake inhibitor than the parent compound methylphenidate.<ref>Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/8632426</ref><ref>Biochemical and behavioral characterization of novel methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/11961053</ref><ref>Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/15026075</ref><ref>Quantitative structure-activity relationship studies of threo-methylphenidate analogs (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/20846865</ref><ref>Chemistry, Design, and Structure−Activity Relationship of Cocaine Antagonists | http://pubs.acs.org/doi/abs/10.1021/cr9700538</ref>
-F-MPH has little to no history of human usage prior to its availability on the [[research chemical]] market. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 due to a temporary blanket ban, which later became permanent. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>
+F-MPH has little to no history of human usage prior to its availability by vendors on the online [[research chemical]] market. It was initially developed as a replacement for [[ethylphenidate]] which became illegal in the United Kingdom on April 2015 due to a temporary blanket ban, which later became permanent. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as [[anxiety]], [[muscle spasms]] and [[compulsive redosing]].<ref>http://www.bluelight.org/vb/threads/770658-4-Fluoromethylphenidate-(4F-MPH)</ref>
 ==Chemistry==