6-APDB: Difference between revisions

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| ''[[6-APDB/Summary|Summary sheet: 6-APDB]]''

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'''6-APDB''' (also known as '''6-(2-aminopropyl)-2,3-dihydrobenzofuran''' or '''4-Desoxy-MDA''') is a [[stimulant]] and [[Psychoactive class::entactogen]]ic [[research chemical]] of the [[Chemical class::phenethylamine]] and [[Chemical class::benzofuran|benzofuran]] classes. It is a closely related synthetic analogue of [[MDA]] and [[6-APB]] and broadly shares the characteristics of serotonin-selective triple monoamine releasers and [[reuptake inhibitors]] associated with other [[entactogen]]ic or [[empathogen]]ic compounds.

'''6-APDB''' (also known as '''6-(2-aminopropyl)-2,3-dihydrobenzofuran''' or '''4-Desoxy-MDA''') is a [[stimulant]] and [[Psychoactive class::entactogen]]ic [[research chemical]] of the [[Chemical class::phenethylamine]] and [[Chemical class::benzofuran|benzofuran]] classes. It is a closely related synthetic analogue of [[MDA]] and [[6-APB]] and broadly shares the characteristics of serotonin-selective triple [[monoamine releasers]] and [[reuptake inhibitors]] associated with other [[entactogen]]ic or [[empathogen]]ic compounds.

6-APDB was first synthesized and studied along with 5-APDB in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]]<ref> "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine"|https://www.ncbi.nlm.nih.gov/pubmed/8246240</ref>. It did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market, in particular the "legal highs" market in the U.K., before its sale and import were subsequently banned.

6-APDB was first synthesized and studied along with [[5-APDB]] in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]]<ref> "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine"|https://www.ncbi.nlm.nih.gov/pubmed/8246240</ref>. It did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market, in particular the "legal highs" market in the U.K., before its sale and import were subsequently banned.

Because 6-APDB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for serotonergic [[entactogens]] like [[MDMA]] or [[MDA]], and are typically distributed through the online [[research ~~chemical]]s~~ grey market.

Because 6-APDB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for serotonergic [[entactogens]] like MDMA or MDA, and are typically distributed through the online research chemicals grey market.

==Chemistry==

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 | ''[[6-APDB/Summary|Summary sheet: 6-APDB]]''
 |}
-'''6-APDB''' (also known as '''6-(2-aminopropyl)-2,3-dihydrobenzofuran''' or '''4-Desoxy-MDA''') is a [[stimulant]] and [[Psychoactive class::entactogen]]ic [[research chemical]] of the [[Chemical class::phenethylamine]] and [[Chemical class::benzofuran|benzofuran]] classes. It is a closely related synthetic analogue of [[MDA]] and [[6-APB]] and broadly shares the characteristics of serotonin-selective triple monoamine releasers and [[reuptake inhibitors]] associated with other [[entactogen]]ic or [[empathogen]]ic compounds.
+'''6-APDB''' (also known as '''6-(2-aminopropyl)-2,3-dihydrobenzofuran''' or '''4-Desoxy-MDA''') is a [[stimulant]] and [[Psychoactive class::entactogen]]ic [[research chemical]] of the [[Chemical class::phenethylamine]] and [[Chemical class::benzofuran|benzofuran]] classes. It is a closely related synthetic analogue of [[MDA]] and [[6-APB]] and broadly shares the characteristics of serotonin-selective triple [[monoamine releasers]] and [[reuptake inhibitors]] associated with other [[entactogen]]ic or [[empathogen]]ic compounds.
--APDB was first synthesized and studied along with 5-APDB in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]]<ref> "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine"|https://www.ncbi.nlm.nih.gov/pubmed/8246240</ref>. It did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market, in particular the "legal highs" market in the U.K., before its sale and import were subsequently banned.
+-APDB was first synthesized and studied along with [[5-APDB]] in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]]<ref> "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine"|https://www.ncbi.nlm.nih.gov/pubmed/8246240</ref>. It did not come into popular recreational use until over a decade later, where it briefly entered the rave scene and global research chemicals market, in particular the "legal highs" market in the U.K., before its sale and import were subsequently banned.
-Because 6-APDB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for serotonergic [[entactogens]] like [[MDMA]] or [[MDA]], and are typically distributed through the online [[research chemical]]s grey market.
+Because 6-APDB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for serotonergic [[entactogens]] like MDMA or MDA, and are typically distributed through the online research chemicals grey market.
 ==Chemistry==