Alpha-GPC: Difference between revisions

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| ''[[Alpha-GPC/Summary|Summary sheet: Alpha-GPC]]''

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'''Alpha-GPC''' ('''alpha-glycerophosphocholine''', '''choline alfoscerate''') is a water soluble nutrient which serves as a precursor to both [[choline]] and glycerophosphate within the brain. In humans, choline is considered to be an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies ~~have~~ been well documented.<ref>Choline: An Essential Nutrient for Public Health | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/</ref>

'''Alpha-GPC''' ('''alpha-glycerophosphocholine''', '''choline alfoscerate''') is a water soluble nutrient which serves as a precursor to both [[choline]] and glycerophosphate within the brain. In humans, choline is considered to be an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies has been well documented.<ref>Choline: An Essential Nutrient for Public Health | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/</ref>

Notably, alpha-GPC is one of the three choline-containing phospholipids that can be orally supplemented (the other two being [[citicoline]] and phosphatidylcholine) and its popularity may be due to it being the most efficient pro-drug of choline (with the ability to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), ~~alpha-GPC~~ also appears to support the structure and maintenance of cellular membranes, similarly to [[citicoline]].

Notably, alpha-GPC is one of the three choline-containing phospholipids that can be orally supplemented (the other two being [[citicoline]] and phosphatidylcholine) and its popularity may be due to it being the most efficient pro-drug of choline (with the ability to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), it also appears to support the structure and maintenance of cellular membranes, similarly to [[citicoline]].

Athletes have been known to use alpha-GPC due to its purported ability to enhance growth hormone production and to enhance power output (which is based on lone pilot study in support of subjects ingesting 600 mg alpha-GPC prior to exercise<ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>).

Athletes have been known to use alpha-GPC due to its purported ability to enhance growth hormone production and to enhance power output (which is based on a lone pilot study in support of subjects ingesting 600 mg alpha-GPC prior to exercise<ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>).

When taken as supplement, this compound has [[psychoactive class::nootropic]] effects which may have potential for the treatment of Alzheimer's disease<ref>Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | https://www.ncbi.nlm.nih.gov/pubmed/17331541</ref> and other related disorders.<ref>Treatment of dementia with neurotransmission modulation | https://www.ncbi.nlm.nih.gov/pubmed/14519085</ref> It is easily available and commonly sold for this purpose via online supplement and nootropic vendors.

When taken as a supplement, this compound has [[psychoactive class::nootropic]] effects which may have potential for the treatment of Alzheimer's disease<ref>Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | https://www.ncbi.nlm.nih.gov/pubmed/17331541</ref> and other related disorders.<ref>Treatment of dementia with neurotransmission modulation | https://www.ncbi.nlm.nih.gov/pubmed/14519085</ref> It is easily available and commonly sold for this purpose via online supplement and nootropic vendors.

==Chemistry==

Alpha-GPC is a naturally occurring choline compound found endogenously in the brain which is also synthesized for oral consumption. Structurally, alpha-GPC is comprised of a choline group bound to a glycerol molecule via a phosphate group.

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 | ''[[Alpha-GPC/Summary|Summary sheet: Alpha-GPC]]''
 |}
-'''Alpha-GPC''' ('''alpha-glycerophosphocholine''', '''choline alfoscerate''') is a water soluble nutrient which serves as a precursor to both [[choline]] and glycerophosphate within the brain. In humans, choline is considered to be an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies have been well documented.<ref>Choline: An Essential Nutrient for Public Health | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/</ref>
+'''Alpha-GPC''' ('''alpha-glycerophosphocholine''', '''choline alfoscerate''') is a water soluble nutrient which serves as a precursor to both [[choline]] and glycerophosphate within the brain. In humans, choline is considered to be an essential nutrient as its role in reducing the risk of neural tube defects, fatty liver disease, and other pathologies has been well documented.<ref>Choline: An Essential Nutrient for Public Health | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/</ref>
-Notably, alpha-GPC is one of the three choline-containing phospholipids that can be orally supplemented (the other two being [[citicoline]] and phosphatidylcholine) and its popularity may be due to it being the most efficient pro-drug of choline (with the ability to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure and maintenance of cellular membranes, similarly to [[citicoline]].
+Notably, alpha-GPC is one of the three choline-containing phospholipids that can be orally supplemented (the other two being [[citicoline]] and phosphatidylcholine) and its popularity may be due to it being the most efficient pro-drug of choline (with the ability to influence both systemic and brain concentrations of choline). Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), it also appears to support the structure and maintenance of cellular membranes, similarly to [[citicoline]].
-Athletes have been known to use alpha-GPC due to its purported ability to enhance growth hormone production and to enhance power output (which is based on lone pilot study in support of subjects ingesting 600 mg alpha-GPC prior to exercise<ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>).
+Athletes have been known to use alpha-GPC due to its purported ability to enhance growth hormone production and to enhance power output (which is based on a lone pilot study in support of subjects ingesting 600 mg alpha-GPC prior to exercise<ref>http://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15</ref>).
-When taken as supplement, this compound has [[psychoactive class::nootropic]] effects which may have potential for the treatment of Alzheimer's disease<ref>Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | https://www.ncbi.nlm.nih.gov/pubmed/17331541</ref> and other related disorders.<ref>Treatment of dementia with neurotransmission modulation | https://www.ncbi.nlm.nih.gov/pubmed/14519085</ref> It is easily available and commonly sold for this purpose via online supplement and nootropic vendors.
+When taken as a supplement, this compound has [[psychoactive class::nootropic]] effects which may have potential for the treatment of Alzheimer's disease<ref>Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | https://www.ncbi.nlm.nih.gov/pubmed/17331541</ref> and other related disorders.<ref>Treatment of dementia with neurotransmission modulation | https://www.ncbi.nlm.nih.gov/pubmed/14519085</ref> It is easily available and commonly sold for this purpose via online supplement and nootropic vendors.
 ==Chemistry==
 Alpha-GPC is a naturally occurring choline compound found endogenously in the brain which is also synthesized for oral consumption. Structurally, alpha-GPC is comprised of a choline group bound to a glycerol molecule via a phosphate group.