Hexedrone: Difference between revisions

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'''Hexedrone''' is a [[research chemical]] [[Stimulant|stimulant]] that falls within the [[Cathinone|cathinone]] category. Considering its effects and its structure being closely related to [[Pentedrone]], this too is likely to be a Norepinephrine-Dopamine-reuptake-inhibitor (NDRI). However, these assumptions have not ~~yet~~ been confirmed, due to insufficient research.

'''Hexedrone''' is a [[research chemical]] [[Stimulant|stimulant]] that falls within the [[Cathinone|cathinone]] category. Considering its effects and its structure being closely related to [[Pentedrone]], this too is likely to be a Norepinephrine-Dopamine-reuptake-inhibitor (NDRI). However, these assumptions have not already been confirmed, due to insufficient research.

Due to the lack of research along with only little experience-based information, the presented data might turn out to have some inaccuracies. This should especially be taken into consideration when interpreting the dosage information.

==Chemistry==

Hexedrone is a [[Cathinone|substituted cathinone]], which ~~are~~ closely related to [[Amphetamines|amphetamines]], but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R2 position, an n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that's ~~connected~~ to the amine (R4), thus forming N-Methyl.

Hexedrone is a [[Cathinone|substituted cathinone]], which is closely related to [[Amphetamines|amphetamines]], but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R2 position, a n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that's attached to the amine (R4), thus forming N-Methyl.

==Pharmacology==

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other [[cathinone]]s such as [[Pentedrone|pentedrone]] and others. Hexedrone most likely acts as both a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]]. This allows dopamine and norepinephrine to ~~accumulate~~ within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects. The decreased potency, compared to both pentedrone as well as [[Ethyl-Hexedrone|ethyl-hexedrone]] can be easily explained. Compared to pentedrone, there's a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.

Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other [[cathinone]]s such as [[Pentedrone|pentedrone]] and others. Hexedrone most likely acts as both a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]]. This allows dopamine and norepinephrine to build up within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects. The decreased potency, compared to both pentedrone as well as [[Ethyl-Hexedrone|ethyl-hexedrone]] can be easily explained. Compared to pentedrone, there's a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.

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The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

===Physical effects===

*'''[[Effect::Spontaneous tactile sensations]]''' - High doses of hexedrone result in a pleasurable body ~~high~~ characterized by pleasant tingling.

*'''[[Effect::Spontaneous tactile sensations]]''' - High doses of hexedrone result in a pleasurable body highly characterized by pleasant tingling.

*'''[[Effect::Stimulation]]''' - In terms of its effects on the user's physical energy levels, hexedrone can be considered to be extremely stimulating and energetic.

*'''[[Effect::Dehydration]]''' - Dry mouth and increased sweating can occur after consuming hexedrone. Low doses of the substance in question cause minimal dehydration.

@@ Line 8: / Line 8: @@
 {{SubstanceBox/Hexedrone}}
-'''Hexedrone''' is a [[research chemical]] [[Stimulant|stimulant]] that falls within the [[Cathinone|cathinone]] category. Considering its effects and its structure being closely related to [[Pentedrone]], this too is likely to be a Norepinephrine-Dopamine-reuptake-inhibitor (NDRI). However, these assumptions have not yet been confirmed, due to insufficient research.
+'''Hexedrone''' is a [[research chemical]] [[Stimulant|stimulant]] that falls within the [[Cathinone|cathinone]] category. Considering its effects and its structure being closely related to [[Pentedrone]], this too is likely to be a Norepinephrine-Dopamine-reuptake-inhibitor (NDRI). However, these assumptions have not already been confirmed, due to insufficient research.
 Due to the lack of research along with only little experience-based information, the presented data might turn out to have some inaccuracies. This should especially be taken into consideration when interpreting the dosage information.
 ==Chemistry==
-Hexedrone is a [[Cathinone|substituted cathinone]], which are closely related to [[Amphetamines|amphetamines]], but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R<sub>2</sub> position, an n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that's connected to the amine (R<sub>4</sub>), thus forming N-Methyl.
+Hexedrone is a [[Cathinone|substituted cathinone]], which is closely related to [[Amphetamines|amphetamines]], but have a ß-substituted ketone group as well. Relative to regular cathinone, which can be found in the Khat plant, hexedrone consists of two added substitutions. At the R<sub>2</sub> position, a n-Butyl substitution forms a hexan chain. The second substitution is a Methyl group, that's attached to the amine (R<sub>4</sub>), thus forming N-Methyl.
 ==Pharmacology==
 <!-- This section was almost entirely copied from Ethyl-Hexedrone, due to their similarity. -->
-Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other [[cathinone]]s such as [[Pentedrone|pentedrone]] and others. Hexedrone most likely acts as both a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]]. This allows dopamine and norepinephrine to accumulate within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects. The decreased potency, compared to both pentedrone as well as [[Ethyl-Hexedrone|ethyl-hexedrone]] can be easily explained. Compared to pentedrone, there's a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.
+Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other [[cathinone]]s such as [[Pentedrone|pentedrone]] and others. Hexedrone most likely acts as both a [[dopamine]] and [[norepinephrine]] [[reuptake inhibitor]]. This allows dopamine and norepinephrine to build up within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects. The decreased potency, compared to both pentedrone as well as [[Ethyl-Hexedrone|ethyl-hexedrone]] can be easily explained. Compared to pentedrone, there's a larger non-polar side chain. Ethyl-hexedrone has an ethyl group, instead of a methyl, which results in a significantly shifted electronegativity.
 <!-- START copy paste -->
@@ Line 23: / Line 23: @@
 The effects listed below are based upon the [[subjective effects index]] and personal experiences of [[PsychonautWiki]] [[Special:TopUsers|contributors]]. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
 ===Physical effects===
-*'''[[Effect::Spontaneous tactile sensations]]''' - High doses of hexedrone result in a pleasurable body high characterized by pleasant tingling.
+*'''[[Effect::Spontaneous tactile sensations]]''' - High doses of hexedrone result in a pleasurable body highly characterized by pleasant tingling.
 *'''[[Effect::Stimulation]]''' - In terms of its effects on the user's physical energy levels, hexedrone can be considered to be extremely stimulating and energetic.
 *'''[[Effect::Dehydration]]''' - Dry mouth and increased sweating can occur after consuming hexedrone. Low doses of the substance in question cause minimal dehydration.