PMMA: Difference between revisions

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==Pharmacology==

PMMA, like [[PMA]] most likely acts as a [[selective serotonin releasing agent]] (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to [[MDMA]], it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMMA has also been shown to act as a potent, reversible inhibitor of the enzyme [[MAOI|MAO-A]] with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential. It is likely metabolized to PMA in the body, like methamphetamine is metabolized to amphetamine.

PMMA, like [[PMA]] most likely acts as a [[selective serotonin releasing agent]] (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to [[MDMA]], it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMMA has also been shown to act as a potent, reversible inhibitor of the enzyme [[MAOI|MAO-A]] with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential. It is likely metabolized to PMA in the body, just like [[methamphetamine]] is metabolized to [[amphetamine]].

It appears that PMMA elevates body temperatures dramatically; the cause of this property is suspected to be related to its ability to inhibit MAO-A and at the same time releasing large amounts of serotonin, effectively causing [[serotonin syndrome]]. It appears that PMMA activates the hypothalamus much more strongly than MDMA and other drugs like [[ephedrine]], thereby causing rapid increases in body temperature (which is the major cause of death in PMMA mortalities).

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 ==Pharmacology==
 {{pharmacology}}
-PMMA, like [[PMA]] most likely acts as a [[selective serotonin releasing agent]] (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to [[MDMA]], it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMMA has also been shown to act as a potent, reversible inhibitor of the enzyme [[MAOI|MAO-A]] with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential. It is likely metabolized to PMA in the body, like methamphetamine is metabolized to amphetamine.
+PMMA, like [[PMA]] most likely acts as a [[selective serotonin releasing agent]] (SSRA) with weak effects on dopamine and norepinephrine transporters. However, relative to [[MDMA]], it is considerably less effective as a releaser of serotonin with properties more akin to a reuptake inhibitor in comparison. It evokes robust hyperthermia while producing only modest hyperactivity and serotonergic neurotoxicity, substantially lower than that caused by MDMA. Anecdotal reports suggest it is not particularly euphoric at all, perhaps even dysphoric in contrast. PMMA has also been shown to act as a potent, reversible inhibitor of the enzyme [[MAOI|MAO-A]] with no significant effects on MAO-B, and the combination of this property and serotonin release is likely responsible for its high lethality potential. It is likely metabolized to PMA in the body, just like [[methamphetamine]] is metabolized to [[amphetamine]].
 It appears that PMMA elevates body temperatures dramatically; the cause of this property is suspected to be related to its ability to inhibit MAO-A and at the same time releasing large amounts of serotonin, effectively causing [[serotonin syndrome]]. It appears that PMMA activates the hypothalamus much more strongly than MDMA and other drugs like [[ephedrine]], thereby causing rapid increases in body temperature (which is the major cause of death in PMMA mortalities).