Alpha-GPC: Difference between revisions
>Kaylee No edit summary |
>Kaylee No edit summary |
||
Line 14: | Line 14: | ||
When taken as supplement, this compound has [[psychoactive class::nootropic]] effects which may have potential for the treatment of Alzheimer's disease<ref>Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | https://www.ncbi.nlm.nih.gov/pubmed/17331541</ref> and other dementias.<ref>Treatment of dementia with neurotransmission modulation | https://www.ncbi.nlm.nih.gov/pubmed/14519085</ref> It is easily available and commonly sold for this purpose through the use of online supplement vendors. | When taken as supplement, this compound has [[psychoactive class::nootropic]] effects which may have potential for the treatment of Alzheimer's disease<ref>Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation? | https://www.ncbi.nlm.nih.gov/pubmed/17331541</ref> and other dementias.<ref>Treatment of dementia with neurotransmission modulation | https://www.ncbi.nlm.nih.gov/pubmed/14519085</ref> It is easily available and commonly sold for this purpose through the use of online supplement vendors. | ||
==Chemistry== | ==Chemistry== | ||
Alpha-GPC is a naturally occurring choline compound found endogenously in the brain which is also synthesized for oral consumption. Structurally, alpha-GPC is comprised of a choline group bound to a glycerol molecule via a phosphate group. Choline is a quaternary ammonium salt, containing a positively charged ammonium cation substituted with three methyl groups and a hydroxyethyl chain. Glycerol is a poly substituted alcohol consisting of a propane with one hydroxyl (OH) group bound to each carbon in the chain. In alpha-GPC, the terminal oxygen of the choline chain and a primary hydroxy group of glycerol are integrated as a bridging oxygens into a phosphate group. This phosphate group is a quaternary substituted phosphorus atom connected to four oxygen atoms, two of which serve to bind the choline, glycerol and phosphate groups into a unified structure. | |||
Alpha-GPC is a naturally occurring choline compound found endogenously in the brain which is also synthesized for oral consumption. Structurally, alpha-GPC is comprised of a choline group bound to a glycerol molecule via a phosphate group. Choline is a quaternary ammonium salt, containing a positively charged ammonium cation substituted with three methyl groups and a hydroxyethyl chain. Glycerol is a poly substituted alcohol consisting of a propane with one hydroxyl (OH) group bound to each carbon in the chain. In alpha-GPC, the terminal oxygen of the choline chain and a primary hydroxy group of glycerol are integrated as a bridging oxygens into a phosphate group. | |||
==Pharmacology== | ==Pharmacology== |