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Serotonin: Difference between revisions
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Most classical psychedelic drugs are partial agonists of the 5-HT<sub>2A</sub> receptor; among them are [[LSD]], [[psilocin]] and [[mescaline]]. Many antidepressants, anxiolytics/anti-anxiety drugs, and cluster headache medicines are partial serotonin receptor agonists. | Most classical psychedelic drugs are partial agonists of the 5-HT<sub>2A</sub> receptor; among them are [[LSD]], [[psilocin]] and [[mescaline]]. Many antidepressants, anxiolytics/anti-anxiety drugs, and cluster headache medicines are partial serotonin receptor agonists. | ||
===Inverse agonists=== | ====Inverse agonists==== | ||
A serotonin [[agonist#Inverse agonists |inverse agonist]] activates a serotonin receptor but has the opposite pharmacological effect. Inverse agonists trigger a specific response from a receptor, whereas antagonists inhibit the activity of the receptor. | A serotonin [[agonist#Inverse agonists |inverse agonist]] activates a serotonin receptor but has the opposite pharmacological effect. Inverse agonists trigger a specific response from a receptor, whereas antagonists inhibit the activity of the receptor. | ||
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Many recreational drugs are serotonin releasing agents; among them are [[MDMA]], [[MDA]] and [[mephedrone]]. Many analgesics/pain-relievers and appetite suppressants are also serotonin releasing agents. | Many recreational drugs are serotonin releasing agents; among them are [[MDMA]], [[MDA]] and [[mephedrone]]. Many analgesics/pain-relievers and appetite suppressants are also serotonin releasing agents. | ||
===Reuptake inhibitor=== | ====Reuptake inhibitor==== | ||
A serotonin [[reuptake inhibitor]] inhibits the reabsorption of serotonin into the pre-synaptic neuron. Serotonin reuptake inhibitors do this by inhibiting the serotonin transporter, or SERT protein. | A serotonin [[reuptake inhibitor]] inhibits the reabsorption of serotonin into the pre-synaptic neuron. Serotonin reuptake inhibitors do this by inhibiting the serotonin transporter, or SERT protein. | ||