5-Hydroxytryptophan: Difference between revisions

Line 20:

Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.<ref>https://www.ncbi.nlm.nih.gov/pubmed/15781732 | Long-term serotonin administration induces heart valve disease in rats.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/12466135 | Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.</ref>

It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.<ref>https://www.ncbi.nlm.nih.gov/pubmed/7699627 | An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan.</ref>

It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements instead of the drug itself.<ref>https://www.ncbi.nlm.nih.gov/pubmed/7699627 | An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan.</ref>

===Dangerous interactions===

Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Line 31:

*'''[[Tricyclic antidepressants]] (TCAs)'''

*'''[[DangerousInteraction::Tramadol]]'''

==Legal issues==

@@ Line 20: / Line 20: @@
 Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.<ref>https://www.ncbi.nlm.nih.gov/pubmed/15781732 | Long-term serotonin administration induces heart valve disease in rats.</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/12466135 | Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.</ref>
-It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.<ref>https://www.ncbi.nlm.nih.gov/pubmed/7699627 | An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan.</ref>
+It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements instead of the drug itself.<ref>https://www.ncbi.nlm.nih.gov/pubmed/7699627 | An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan.</ref>
 ===Dangerous interactions===
 Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
@@ Line 31: / Line 31: @@
 *'''[[Tricyclic antidepressants]] (TCAs)'''
 *'''[[DangerousInteraction::Tramadol]]'''
 ==Legal issues==
 {{LegalStub}}