5-Hydroxytryptophan: Difference between revisions

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It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.[17]

===Dangerous interactions===

When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9] ~~In humans~~, 5-~~HTP has never been clinically associated with~~ serotonin syndrome, ~~although~~ 5-HTP ~~can precipitate mania when added to a MAOI~~.[10]

When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9]

Combinations in the list below may increase the amount of neurotransmitters, such as serotonin, to dangerous or even fatal levels, resulting in life-threatening [[serotonin syndrome]].

*'''[[DangerousInteraction::Selective serotonin re-uptake inhibitors]] (SSRIs)'''

*'''[[DangerousInteraction::Serotonin releasers]]''' such as '''[[MDMA]]''', '''[[4-FA]]''', '''[[MDAI]]''' and '''[[αMT]]''' - 5-HTP should only be taken once the user has come down from the MDMA, roughly 12 hours after the last dose.

*'''[[DangerousInteraction::MAOIs]]''' such as '''[[syrian rue]]''', '''[[banisteriopsis caapi]]''', '''[[2C-T-2]]''', '''[[2C-T-7]]''', '''[[αMT]]''', and some [[antidepressants]]

*'''[[DangerousInteraction::Tramadol]]'''

==See also==

*[[Serotonin syndrome]]

@@ Line 8: / Line 8: @@
 It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.[17]
 ===Dangerous interactions===
-When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9] In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a MAOI.[10]
+When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9]
+Combinations in the list below may increase the amount of neurotransmitters, such as serotonin, to dangerous or even fatal levels, resulting in life-threatening [[serotonin syndrome]].
+*'''[[DangerousInteraction::Selective serotonin re-uptake inhibitors]] (SSRIs)'''
+*'''[[DangerousInteraction::Serotonin releasers]]''' such as '''[[MDMA]]''', '''[[4-FA]]''', '''[[MDAI]]''' and '''[[αMT]]''' - 5-HTP should only be taken once the user has come down from the MDMA, roughly 12 hours after the last dose.
+*'''[[DangerousInteraction::MAOIs]]''' such as '''[[syrian rue]]''', '''[[banisteriopsis caapi]]''', '''[[2C-T-2]]''', '''[[2C-T-7]]''', '''[[αMT]]''', and some [[antidepressants]]
+*'''[[DangerousInteraction::Tramadol]]'''
 ==See also==
 *[[Serotonin syndrome]]