5-Hydroxytryptophan: Difference between revisions

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==Toxicity and harm potential==

Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.

Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.[15][16]

It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.

It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.[17]

===Dangerous interactions===

When combined with antidepressants of the [[MAOI]] or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats. In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a [~~[MAOI~~]].

When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9] In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a MAOI.[10]

==See also==

*[[Serotonin syndrome]]

@@ Line 4: / Line 4: @@
 ==Toxicity and harm potential==
-Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.
+Due to the conversion of 5-HTP into serotonin by the liver, there may be a significant risk of heart valve disease from serotonin's effect on the heart.[15][16]
-It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.
+It has been suggested that 5-HTP may cause eosinophilia-myalgia syndrome (EMS), a serious condition which results in extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence to show that EMS was likely caused by a contaminant in certain 5-HTP supplements.[17]
 ===Dangerous interactions===
-When combined with antidepressants of the [[MAOI]] or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats. In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a [[MAOI]].
+When combined with antidepressants of the MAOI or SSRI class, high doses of 5-HTP can cause acute serotonin syndrome in rats.[8][9] In humans, 5-HTP has never been clinically associated with serotonin syndrome, although 5-HTP can precipitate mania when added to a MAOI.[10]
 ==See also==
 *[[Serotonin syndrome]]