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6-APB: Difference between revisions
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| ''[[6-APB/Summary|Summary sheet: 6-APB]]'' | | ''[[6-APB/Summary|Summary sheet: 6-APB]]'' | ||
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'''6-APB''' '''(6-(2-aminopropyl)benzofuran''' or '''benzofury''') is a [[stimulant]] and [[Psychoactive class::entactogen]]ic [[research chemical]] of the [[Chemical class::phenethylamine]], [[Chemical class::Substituted amphetamines|amphetamine]] and [[Chemical class::benzofuran|benzofuran]] class. It is a close synthetic analogue | '''6-APB''' '''(6-(2-aminopropyl)benzofuran''' or '''benzofury''') is a [[stimulant]] and [[Psychoactive class::entactogen]]ic [[research chemical]] of the [[Chemical class::phenethylamine]], [[Chemical class::Substituted amphetamines|amphetamine]] and [[Chemical class::benzofuran|benzofuran]] class. It is a close synthetic analogue of [[MDA]] and broadly shares the characteristic of serotonergic triple monoamine inhibitors and other [[entactogen]]ic or [[empathogen]]ic compounds. | ||
6-APB was first synthesized and studied in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]]. It did not come into popular use until over a decade later, where briefly entered the rave and underground clubbing scene in the UK before its sale and import were subsequently banned. Because 6-APB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for [ | 6-APB was first synthesized and studied in 1993 by [[David E. Nichols]] as a potential non-neurotoxic alternative to [[MDMA]]. It did not come into popular recreational use until over a decade later, where briefly entered the rave and underground clubbing scene in the UK before its sale and import were subsequently banned. Because 6-APB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for [MDMA]] or [MDA]. | ||
==Chemistry== | ==Chemistry== | ||
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===Long-term health concerns=== | ===Long-term health concerns=== | ||
The neurotoxicity of 6-APB is highly debatable. While designed to be less | The neurotoxicity of 6-APB is highly debatable. While specifically designed to be less neurotoxic than MDA or MDMA through the avoidance of producing certain metabolic byproducts thought to underlie its toxicity, scientific study has resulted in the general agreement that, although it is physically safe to try in a responsible context, the administration of repeated or high dosages of 6-APB is most certainly neurotoxic in some form or otherwise results in cognitive, affective and psychomotor degradation. | ||
As with MDMA, long-term heavy use of 6-APB is likely cardiotoxic and | As with MDMA, long-term heavy use of 6-APB is likely cardiotoxic and thought to lead to valvulopathy through its actions on the 5-HT2B receptor.<ref> Drug-induced Valvulopathy: An Update | tpx.sagepub.com/content/38/6/837.full</ref> In one study, 28% of long-term users (2-3 doses per week for a mean of 6 years, mean of age 24.3 years) had developed clinically evident valvular heart disease.<ref>Possible association between 3,4-methylenedioxymethamphetamine abuse and valvular heart disease. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/17950805</ref> | ||
It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug. | It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug. | ||
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{{DangerousInteractions/MAOI|nt=dopamine}} | {{DangerousInteractions/MAOI|nt=dopamine}} | ||
*'''[[DangerousInteraction::Stimulants]]''' - The neurotoxic effects of 6-APBmay be increased when combined with other stimulants. | *'''[[DangerousInteraction::Stimulants]]''' - The neurotoxic effects of 6-APBmay be increased when combined with other stimulants. | ||
*'''[[DangerousInteraction::Cocaine]]''' - This combination may | *'''[[DangerousInteraction::Cocaine]]''' - This combination may cause unbearable combined strain on the heart, resulting in heart attack or stroke. | ||
====[[Serotonin syndrome]] risk==== | ====[[Serotonin syndrome]] risk==== | ||
{{DangerousInteractions/SerotoninSyndrome}} | {{DangerousInteractions/SerotoninSyndrome}} | ||