Releasing agent: Difference between revisions

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==Mechanism of Action==

Releasing agents cause the release of neurotransmitters by first entering the presynaptic neurone, primarily via membrane transporters. Some, such as [[amphetamine]] and [[methamphetamine]], can also diffuse directly across the cell membrane. Next, they inhibit vesicular uptake of the neurotransmitter by interfering with a vesicular transporter, ~~and~~ thus ~~inhibit~~ the repackaging of the neurotransmitter from the pre-synaptic neurone into vesicles. Finally, releasing agents reverse the action of reuptake receptors, allowing the neurotransmitter to flow out from the pre-synaptic neurone into the nerve terminal or synapse. The result is increased neurotransmission.

Releasing agents cause the release of neurotransmitters by first entering the presynaptic neurone, primarily via membrane transporters. Some, such as [[amphetamine]] and [[methamphetamine]], can also diffuse directly across the cell membrane. Next, they inhibit vesicular uptake of the neurotransmitter by interfering with a vesicular transporter, thus inhibiting the repackaging of the neurotransmitter from the pre-synaptic neurone into vesicles. Finally, releasing agents reverse the action of reuptake receptors, allowing the neurotransmitter to flow out from the pre-synaptic neurone into the nerve terminal or synapse. The result is increased neurotransmission.

The postsynaptic effect is enhanced due to the interaction with reuptake receptors; one method by which the action of neurotransmitters is terminated is via reuptake into the presynaptic neuron, and disruption of this process causes further increases in extracellular neurotransmitter concentration.

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 ==Mechanism of Action==
-Releasing agents cause the release of neurotransmitters by first entering the presynaptic neurone, primarily via membrane transporters. Some, such as [[amphetamine]] and [[methamphetamine]], can also diffuse directly across the cell membrane. Next, they inhibit vesicular uptake of the neurotransmitter by interfering with a vesicular transporter, and thus inhibit the repackaging of the neurotransmitter from the pre-synaptic neurone into vesicles. Finally, releasing agents reverse the action of reuptake receptors, allowing the neurotransmitter to flow out from the pre-synaptic neurone into the nerve terminal or synapse. The result is increased neurotransmission.
+Releasing agents cause the release of neurotransmitters by first entering the presynaptic neurone, primarily via membrane transporters. Some, such as [[amphetamine]] and [[methamphetamine]], can also diffuse directly across the cell membrane. Next, they inhibit vesicular uptake of the neurotransmitter by interfering with a vesicular transporter, thus inhibiting the repackaging of the neurotransmitter from the pre-synaptic neurone into vesicles. Finally, releasing agents reverse the action of reuptake receptors, allowing the neurotransmitter to flow out from the pre-synaptic neurone into the nerve terminal or synapse. The result is increased neurotransmission.
 The postsynaptic effect is enhanced due to the interaction with reuptake receptors; one method by which the action of neurotransmitters is terminated is via reuptake into the presynaptic neuron, and disruption of this process causes further increases in extracellular neurotransmitter concentration.